| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4199595 | F | Antileishmanial activity against Leishmania infantum MHOM/TN/80/IPT1 promastigotes after 72 hrs by MTT assay | Leishmania infantum | 31 | organism-based format | Scientific Literature | ||
| 2. | ALA4199596 | F | Antileishmanial activity against Leishmania tropica MHOM/IT/2012/ISS3130 promastigotes after 72 hrs by MTT assay | Leishmania tropica | 31 | organism-based format | Scientific Literature | ||
| 3. | ALA4199597 | A | Cytotoxicity against PMA-differentiated human THP1 cells after 72 hrs by MTT assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 4. | ALA4199598 | T | Selectivity index, ratio of IC50 for PMA-differentiated human THP1 cells to IC50 for Leishmania infantum MHOM/TN/80/IPT1 promastigotes | 31 | assay format | Scientific Literature | |||
| 5. | ALA4199599 | T | Selectivity index, ratio of IC50 for PMA-differentiated human THP1 cells to IC50 for Leishmania tropica MHOM/IT/2012/ISS3130 promastigotes | 31 | assay format | Scientific Literature | |||
| 6. | ALA4199600 | F | Antileishmanial activity against amastigote stage of Leishmania infantum infected in PMA-differentiated human THP1 cells assessed as inhibition of parasite growth at 0.5 uM after 72 hrs by Giemsa staining based light microscopy relative to control | Leishmania infantum | 11 | organism-based format | Scientific Literature | ||
| 7. | ALA4199601 | F | Antileishmanial activity against amastigote stage of Leishmania infantum infected in PMA-differentiated human THP1 cells assessed as inhibition of parasite growth after 72 hrs by Giemsa staining based light microscopy | Leishmania infantum | 11 | organism-based format | Scientific Literature | ||
| 8. | ALA4199602 | T | Selectivity index, ratio of IC50 for PMA-differentiated human THP1 cells to IC50 for amastigote stage of Leishmania infantum infected in PMA-differentiated human THP1 cells | 11 | assay format | Scientific Literature | |||
| 9. | ALA4199603 | T | Toxicity in C57Bl/6 mouse assessed as survival at 300 mg/kg, po administered as single dose measured twice daily up to 30 days | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA4199605 | T | Toxicity in C57Bl/6 mouse assessed as effect on normal appearance at 300 mg/kg, po administered as single dose measured twice daily up to 30 days | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA4199607 | T | Toxicity in C57Bl/6 mouse assessed as effect on normal behavior at 300 mg/kg, po administered as single dose measured twice daily up to 30 days | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA4199610 | F | Antileishmanial activity against Leishmania infantum MHOM/TN/1980/IPT-1 amastigotes infected in Balb/c mouse assessed as reduction in liver parasite load at 100 mg/kg, po administered for 4 days measured post last dose relative to control | Leishmania infantum | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA4199611 | F | Antileishmanial activity against Leishmania infantum MHOM/TN/1980/IPT-1 amastigotes infected in Balb/c mouse assessed as reduction in liver parasite load at 60 mg/kg, po administered for 4 days measured post last dose relative to control | Leishmania infantum | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4199612 | T | Toxicity in Balb/c mouse infected with Leishmania infantum MHOM/TN/1980/IPT-1 amastigotes assessed as death at 100 mg/kg, administered for 4 days measured on day 10 to 12 | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4199613 | F | Antileishmanial activity against Leishmania infantum MHOM/TN/1980/IPT-1 amastigotes infected in Balb/c mouse assessed as reduction in liver parasite load at 10 mg/kg, sc administered for 4 days measured post last dose relative to control | Leishmania infantum | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4199614 | F | Antileishmanial activity against Leishmania infantum MHOM/TN/1980/IPT-1 amastigotes infected in Balb/c mouse assessed as reduction in liver parasite load at 5 mg/kg, sc administered for 5 days measured post last dose relative to control | Leishmania infantum | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4199616 | F | Antileishmanial activity against Leishmania infantum MHOM/TN/1980/IPT-1 amastigotes infected in po dosed Balb/c mouse assessed as reduction in liver parasite load administered for 4 to 5 days measured post last dose | Leishmania infantum | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA4199617 | F | Antileishmanial activity against Leishmania infantum MHOM/TN/1980/IPT-1 amastigotes infected in sc dosed Balb/c mouse assessed as reduction in liver parasite load administered for 4 to 5 days measured post last dose | Leishmania infantum | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA4199618 | F | Induction of nitric oxide production in IFNgamma-primed mouse BMDM measured after 24 hrs by Griess assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4199619 | F | Induction of reactive oxygen species production in IFNgamma-primed mouse BMDM measured after 24 hrs by H2DCFDA probe based assay | Mus musculus | 2 | cell-based format | Scientific Literature |
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