# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4189610 | A | Inhibition of human BMP1 expressed in Escherichia coli assessed as residual activity using Abz-YVADAPK(Dnp)G-OH as substrate at 200 uM by fluorescence assay relative to control | Homo sapiens | 6 | ALA4184323 | assay format | Scientific Literature | |
2. | ALA4189611 | B | Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay | Homo sapiens | 44 | ALA4184323 | assay format | Scientific Literature | |
3. | ALA4189612 | A | Inhibition of recombinant human meprin alpha expressed in insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay | Homo sapiens | 6 | ALA4184323 | cell-based format | Scientific Literature | |
4. | ALA4189628 | A | Inhibition of human MMP2 assessed as residual activity using Mca-PLGL-(DapDnp)-AR-NH2 as substrate at 200 uM by fluorescence assay relative to control | Homo sapiens | 6 | ALA4184323 | single protein format | Scientific Literature | |
5. | ALA4189629 | A | Inhibition of human MMP9 assessed as residual activity using Mca-PLGL-(DapDnp)-AR-NH2 as substrate at 200 uM by fluorescence assay relative to control | Homo sapiens | 6 | ALA4184323 | single protein format | Scientific Literature | |
6. | ALA4189630 | A | Inhibition of human MMP13 assessed as residual activity using Mca-PLGL-(DapDnp)-AR-NH2 as substrate at 200 uM by fluorescence assay relative to control | Homo sapiens | 6 | ALA4184323 | single protein format | Scientific Literature | |
7. | ALA4189631 | A | Inhibition of human ADAM10 assessed as residual activity using Abz-LANAVRSSSR-(DapDnp)-AR-NH2 as substrate at 200 uM by fluorescence assay relative to control | Homo sapiens | 6 | ALA4184323 | single protein format | Scientific Literature | |
8. | ALA4189632 | A | Inhibition of human ADAM17 assessed as residual activity using Abz-LANAVRSSSR-(DapDnp)-AR-NH2 as substrate at 200 uM by fluorescence assay relative to control | Homo sapiens | 6 | ALA4184323 | single protein format | Scientific Literature | |
9. | ALA4189633 | A | Inhibition of recombinant human CYP3A4 expressed in baculosomes assessed as residual activity at 25 uM using BOMCC substrate by fluorescence assay relative to control | Homo sapiens | 6 | ALA4184323 | assay format | Scientific Literature | |
10. | ALA4189634 | A | Inhibition of recombinant human CYP2C9 expressed in baculosomes assessed as residual activity at 25 uM using BOMCC substrate by fluorescence assay relative to control | Homo sapiens | 6 | ALA4184323 | assay format | Scientific Literature | |
11. | ALA4189638 | F | Cytotoxicity in human SH-SY5Y cells assessed as cell viability at 100 uM after 24 hrs by CytoTox-ONE-based assay relative to control | Homo sapiens | 2 | ALA4184323 | cell-based format | Scientific Literature | |
12. | ALA4189639 | F | Cytotoxicity in human HepG2 cells assessed as cell viability at 100 uM after 24 hrs by CytoTox-ONE-based assay relative to control | Homo sapiens | 2 | ALA4184323 | cell-based format | Scientific Literature | |
13. | ALA4189641 | B | Selectivity ratio of IC50 for recombinant human meprin alpha expressed in insect cells to IC50 for recombinant human meprin beta expressed in yeast | Homo sapiens | 2 | ALA4184323 | cell-based format | Scientific Literature |