# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4195900 | Binding | Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measuring reduction in [3H]thymidine incorporation preincubated for 5 days followed by [3H]thymidine addition measured after 18 hrs by liquid scintillation counting method | Homo sapiens | 42 | ALA4190408 | assay format | Scientific Literature | |
2. | ALA4195901 | Binding | Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 mins by ADP-Glo assay | Homo sapiens | 41 | ALA4190408 | assay format | Scientific Literature | |
3. | ALA4195906 | Binding | Inhibition of human ERG by cell based automated patch clamp method | Homo sapiens | 20 | ALA4190408 | cell-based format | Scientific Literature | |
4. | ALA4195907 | ADME | Inhibition of CYP3A4 in human liver microsomes assessed as decrease in midazolam 1-hydroxylation by LC-MS/MS analysis | Homo sapiens | 20 | ALA4190408 | microsome format | Scientific Literature | |
5. | ALA4195909 | Physicochemical | Kinetic solubility of the compound in pH 7.4 solution up to 350 uM after 90 mins | 36 | ALA4190408 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4195920 | Physicochemical | Thermodynamic solubility of the compound in pH 7.4 solution after 90 mins by UVLC-MS analysis | 16 | ALA4190408 | small-molecule physicochemical format | Scientific Literature |