# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4200880 | Functional | Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay | Mus musculus | 67 | ALA4196171 | cell-based format | Scientific Literature | |
2. | ALA4200881 | Functional | Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay relative to NTX2048 | Mus musculus | 67 | ALA4196171 | cell-based format | Scientific Literature | |
3. | ALA4200882 | Functional | Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay | Homo sapiens | 56 | ALA4196171 | cell-based format | Scientific Literature | |
4. | ALA4200883 | Functional | Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay relative to NTX2048 | Homo sapiens | 56 | ALA4196171 | cell-based format | Scientific Literature | |
5. | ALA4200884 | Functional | Increase in total plasma GLP1 level in C57BL/6 mouse at 30 mg/kg, po measured after 8 hrs relative to untreated vehicle control | Mus musculus | 22 | ALA4196171 | organism-based format | Scientific Literature | |
6. | ALA4200885 | Toxicity | Toxicity in C57BL/6 mouse assessed as induction of excessive gallbladder filling by measuring gal bladder weight at 30 mg/kg, po measured after 8 hrs relative to untreated vehicle control | Mus musculus | 22 | ALA4196171 | organism-based format | Scientific Literature | |
7. | ALA4200886 | ADME | Drug concentration in bile/gall bladder of C57BL/6 mouse at 30 mg/kg, po measured after 8 hrs by HPLC and mass spectrometry | Mus musculus | 22 | ALA4196171 | organism-based format | Scientific Literature | |
8. | ALA4200887 | ADME | Plasma concentration in C57BL/6 mouse at 30 mg/kg, po measured after 8 hrs by HPLC and mass spectrometry | Mus musculus | 22 | ALA4196171 | organism-based format | Scientific Literature | |
9. | ALA4200888 | Binding | Activation of human FXR up to 50 uM | Homo sapiens | 3 | ALA4196171 | single protein format | Scientific Literature | |
10. | ALA4200889 | Binding | Activation of human FXR | Homo sapiens | 3 | ALA4196171 | single protein format | Scientific Literature | |
11. | ALA4200890 | Binding | Inhibition of human IBAT expressed in COS cells assessed as reduction in [3H]taurocholic acid uptake | Homo sapiens | 3 | ALA4196171 | cell-based format | Scientific Literature | |
12. | ALA4200891 | Binding | Inhibition of mouse IBAT expressed in COS cells assessed as reduction in [3H]taurocholic acid uptake | Mus musculus | 3 | ALA4196171 | cell-based format | Scientific Literature |