# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4202305 | Binding | Inhibition of recombinant Trypanosoma brucei brucei alternative oxidase using ubiquinol-1 as substrate incubated for 2 mins followed by substrate addition by spectrophotometric method | Trypanosoma brucei brucei | 35 | ALA4196235 | single protein format | Scientific Literature | |
2. | ALA4202306 | Functional | Antiparasitic activity against bloodstream trypomastigote stage of wild type Trypanosoma brucei brucei Lister 427 after 48 hrs by resazurin dye based fluorescence assay | Trypanosoma brucei brucei | 28 | ALA4196235 | organism-based format | Scientific Literature | |
3. | ALA4202307 | ADME | Cytotoxicity against HEK293T cells after 30 hrs by resazurin dye based fluorescence assay | Homo sapiens | 32 | ALA4196235 | cell-based format | Scientific Literature | |
4. | ALA4202308 | Toxicity | Selectivity index, ratio of CC50 for HEK293T cells to EC50 for bloodstream trypomastigote stage of wild type Trypanosoma brucei brucei Lister 427 | 20 | ALA4196235 | assay format | Scientific Literature | ||
5. | ALA4202312 | Functional | Resistant factor, ratio of EC50 for bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 assessed as inhibition of respiration in presence of glycerol to EC50 for bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 assessed as inhibition of respiration in absence of glycerol | Trypanosoma brucei brucei | 7 | ALA4196235 | organism-based format | Scientific Literature | |
6. | ALA4202315 | Functional | Resistance factor, ratio of EC50 for diminazene, pentamidine and melaminophenyl arsenical-resistant bloodstream trypomastigote stage of Trypanosoma brucei brucei B48 harboring TbAT1 deletions to EC50 for bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 | Trypanosoma brucei brucei | 35 | ALA4196235 | organism-based format | Scientific Literature | |
7. | ALA4338313 | Functional | Antileishmanial activity against Leishmania donovani MHOM/ET/67/HU3 promastigote after 72 hrs by MTT assay | Leishmania donovani | 14 | ALA4334518 | organism-based format | Scientific Literature | |
8. | ALA4338315 | Functional | Antileishmanial activity against Leishmania donovani MHOM/ET/67/HU3 intracellular amastigotes infected in human THP1 cells after 96 hrs by prolong-gold antifade-reagent/DAPI staining based assay | Leishmania donovani | 19 | ALA4334518 | organism-based format | Scientific Literature | |
9. | ALA4338320 | Toxicity | Selectivity index, ratio of EC50 for cytotoxicity against human MRC5 cells to EC50 for antileishmanial activity against Leishmania donovani MHOM/ET/67/HU3 amastigotes infected in human THP1 cells | 4 | ALA4334518 | cell-based format | Scientific Literature |