# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4189284 | B | Displacement of (+)-JQ1 from 6H-Thr BRD4 Y390A mutant BD1 (unknown origin) after 30 mins by TR-FRET assay | Homo sapiens | 49 | ALA4184317 | single protein format | Scientific Literature | |
2. | ALA4189285 | B | Displacement of (+)-JQ1 from 6H-Thr BRD4 Y97A mutant BD2 (unknown origin) after 30 mins by TR-FRET assay | Homo sapiens | 49 | ALA4184317 | single protein format | Scientific Literature | |
3. | ALA4189286 | B | Selectivity ratio of IC50 for 6H-Thr BRD4 Y390A mutant BD1 (unknown origin) to IC50 for 6H-Thr BRD4 Y97A mutant BD2 (unknown origin) | Homo sapiens | 46 | ALA4184317 | assay format | Scientific Literature | |
4. | ALA4189287 | P | Chromatographic hydrophobicity index, log D of the compound at pH 7.4 by HPLC method | 47 | ALA4184317 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4189288 | B | Inhibition of human BRD2 BD1 after 30 mins by TR-FRET assay | Homo sapiens | 2 | ALA4184317 | single protein format | Scientific Literature | |
6. | ALA4189289 | B | Inhibition of human BRD2 BD2 after 30 mins by TR-FRET assay | Homo sapiens | 2 | ALA4184317 | single protein format | Scientific Literature | |
7. | ALA4189290 | B | Inhibition of BRD3 BD1 (unknown origin) after 30 mins by TR-FRET assay | Homo sapiens | 2 | ALA4184317 | single protein format | Scientific Literature | |
8. | ALA4189291 | B | Inhibition of BRD3 BD2 (unknown origin) after 30 mins by TR-FRET assay | Homo sapiens | 2 | ALA4184317 | single protein format | Scientific Literature | |
9. | ALA4189292 | B | Inhibition of BRDT BD1 (unknown origin) after 30 mins by TR-FRET assay | Homo sapiens | 2 | ALA4184317 | single protein format | Scientific Literature | |
10. | ALA4189293 | B | Inhibition of BRDT BD2 (unknown origin) after 30 mins by TR-FRET assay | Homo sapiens | 2 | ALA4184317 | single protein format | Scientific Literature | |
11. | ALA4189294 | B | Displacement of Alexa 647 ligand from 6H-Flag-Tev-BRPF1 (622 to 738 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells after 30 mins by TR-FRET assay | Homo sapiens | 2 | ALA4184317 | cell-based format | Scientific Literature | |
12. | ALA4189295 | A | Intrinsic clearance in rat hepatocytes at 0.5 uM assessed per gram of liver after 60 mins by LC-MS/MS method | Rattus norvegicus | 2 | ALA4184317 | cell-based format | Scientific Literature | |
13. | ALA4189296 | A | Intrinsic clearance in human hepatocytes assessed per gram of liver at 0.5 uM after 120 mins by LC-MS/MS method | Homo sapiens | 2 | ALA4184317 | cell-based format | Scientific Literature | |
14. | ALA4189297 | A | Permeability of the compound by PAMPA | 2 | ALA4184317 | assay format | Scientific Literature | ||
15. | ALA4189298 | P | Solubility of the compound in pH 7.4 phosphate buffered saline by chemiluminescent nitrogen detection method | 2 | ALA4184317 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA4189299 | P | Solubility of the compound in FaSSIF at pH 6.5 after 16 hrs by HPLC method | 2 | ALA4184317 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA4189300 | F | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced MCP1 release preincubated for 30 mins followed by LPS challenge measured after 24 hrs by immunoassay | Homo sapiens | 14 | ALA4184317 | cell-based format | Scientific Literature | |
18. | ALA4189301 | F | Antiinflammatory activity in human whole blood assessed as inhibition of LPS-induced MCP1 release preincubated for 30 mins followed by LPS challenge measured after 24 hrs by immunoassay | Homo sapiens | 2 | ALA4184317 | tissue-based format | Scientific Literature | |
19. | ALA4189302 | B | Binding affinity to human partial length DNA-tagged BRD4 isoform long BD1 expressed in bacterial by BROMOscan method | Homo sapiens | 1 | ALA4184317 | assay format | Scientific Literature | |
20. | ALA4189303 | B | Binding affinity to human partial length DNA-tagged BRD4 isoform long BD2 expressed in bacterial by BROMOscan method | Homo sapiens | 1 | ALA4184317 | assay format | Scientific Literature |