# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4184670 | Functional | Agonist activity at human S1P5 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assay | Homo sapiens | 31 | ALA4184094 | cell-based format | Scientific Literature | |
2. | ALA4184671 | Functional | Agonist activity at human S1P1 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assay | Homo sapiens | 31 | ALA4184094 | cell-based format | Scientific Literature | |
3. | ALA4184672 | Functional | Agonist activity at human S1P3 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assay | Homo sapiens | 31 | ALA4184094 | cell-based format | Scientific Literature | |
4. | ALA4184673 | Physicochemical | Aqueous kinetic solubility of the compound by turbidimetric method | 16 | ALA4184094 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4184674 | ADME | Intrinsic clearance in human microsomes assessed per mg protein | Homo sapiens | 16 | ALA4184094 | microsome format | Scientific Literature | |
6. | ALA4184675 | ADME | Half life in human microsomes assessed per mg protein | Homo sapiens | 16 | ALA4184094 | microsome format | Scientific Literature | |
7. | ALA4184676 | Binding | Selectivity ratio of EC50 for human S1P5 receptor expressed in CHO cells to EC50 for human S1P3 receptor expressed in CHO cells | Homo sapiens | 18 | ALA4184094 | cell-based format | Scientific Literature | |
8. | ALA4184677 | Binding | Selectivity ratio of EC50 for human S1P5 receptor expressed in CHO cells to EC50 for human S1P1 receptor expressed in CHO cells | Homo sapiens | 5 | ALA4184094 | cell-based format | Scientific Literature | |
9. | ALA4184678 | ADME | Oral bioavailability in rat | Rattus norvegicus | 1 | ALA4184094 | organism-based format | Scientific Literature | |
10. | ALA4184679 | ADME | Ratio of drug uptake in CNS to plasma in po dosed rat | Rattus norvegicus | 2 | ALA4184094 | organism-based format | Scientific Literature |