| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4188597 | B | Inhibition of human NNMT at 30 uM preincubated for 30 mins followed by nicotinamide substrate and SAM addition measured after 60 mins by fluorescence assay | Homo sapiens | 22 | ALA4184280 | single protein format | Scientific Literature | |
| 2. | ALA4188598 | B | Inhibition of mouse NNMT at 30 uM preincubated for 30 mins followed by nicotinamide substrate and SAM addition measured after 60 mins by fluorescence assay | Mus musculus | 2 | ALA4184280 | single protein format | Scientific Literature | |
| 3. | ALA4188599 | B | Inhibition of NNMT in human U2OS cells assessed as reduction in MNA production after 24 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA4184280 | cell-based format | Scientific Literature | |
| 4. | ALA4188600 | B | Inhibition of NNMT in mouse 3T3L1 cells assessed as reduction in MNA production after 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4184280 | cell-based format | Scientific Literature | |
| 5. | ALA4188601 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 30 mins | Homo sapiens | 1 | ALA4184280 | microsome format | Scientific Literature | |
| 6. | ALA4188602 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining after 30 mins | Rattus norvegicus | 1 | ALA4184280 | microsome format | Scientific Literature | |
| 7. | ALA4188603 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining after 30 mins | Mus musculus | 1 | ALA4184280 | microsome format | Scientific Literature | |
| 8. | ALA4188604 | P | Solubility of the compound | 1 | ALA4184280 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA4188605 | A | Efflux ratio of permeability in human Caco2 cells | Homo sapiens | 1 | ALA4184280 | cell-based format | Scientific Literature | |
| 10. | ALA4188606 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | ALA4184280 | single protein format | Scientific Literature | |
| 11. | ALA4188607 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 1 | ALA4184280 | single protein format | Scientific Literature | |
| 12. | ALA4188608 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 1 | ALA4184280 | single protein format | Scientific Literature | |
| 13. | ALA4188609 | A | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 1 | ALA4184280 | single protein format | Scientific Literature | |
| 14. | ALA4188610 | A | Cmax in C57Bl6/N mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4184280 | organism-based format | Scientific Literature | |
| 15. | ALA4188611 | A | Cmax in C57Bl6/N mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA4184280 | organism-based format | Scientific Literature | |
| 16. | ALA4188612 | A | AUC in C57Bl6/N mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4184280 | organism-based format | Scientific Literature | |
| 17. | ALA4188613 | A | AUC in C57Bl6/N mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA4184280 | organism-based format | Scientific Literature | |
| 18. | ALA4188614 | A | Half life in C57Bl6/N mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4184280 | organism-based format | Scientific Literature | |
| 19. | ALA4188615 | A | Half life in C57Bl6/N mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA4184280 | organism-based format | Scientific Literature | |
| 20. | ALA4188616 | A | Clearance in C57Bl6/N mouse at 10 mg/kg, po or 1 mg/kg, iv | Mus musculus | 1 | ALA4184280 | organism-based format | Scientific Literature |
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