# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4183880 | P | Drug metabolism at 2 mM at acidic pH after 5 days by 31P NMR method | 5 | ALA4177769 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4183881 | B | Inhibition of human NPP1 at 100 uM using pNP-TMP as substrate preincubated for 3 mins followed by substrate addition measured after 15 mins relative to control | Homo sapiens | 4 | ALA4177769 | single protein format | Scientific Literature | |
3. | ALA4183882 | B | Inhibition of human NTPDase1 at 100 uM using ATP as substrate preincubated for 3 mins followed by substrate addition measured after 10 mins by malachite green reagent-based assay | Homo sapiens | 3 | ALA4177769 | single protein format | Scientific Literature | |
4. | ALA4183883 | B | Inhibition of human NTPDase2 at 100 uM using ATP as substrate preincubated for 3 mins followed by substrate addition measured after 10 mins by malachite green reagent-based assay | Homo sapiens | 3 | ALA4177769 | single protein format | Scientific Literature | |
5. | ALA4183884 | B | Inhibition of human NTPDase3 at 100 uM using ATP as substrate preincubated for 3 mins followed by substrate addition measured after 10 mins by malachite green reagent-based assay | Homo sapiens | 4 | ALA4177769 | single protein format | Scientific Literature | |
6. | ALA4183885 | B | Inhibition of human NTPDase8 at 100 uM using ATP as substrate preincubated for 3 mins followed by substrate addition measured after 10 mins by malachite green reagent-based assay | Homo sapiens | 3 | ALA4177769 | single protein format | Scientific Literature | |
7. | ALA4183888 | B | Inhibition of human NPP1 using pNP-TMP as substrate preincubated for 3 mins followed by substrate addition measured after 15 mins | Homo sapiens | 3 | ALA4177769 | single protein format | Scientific Literature | |
8. | ALA4183889 | P | Drug metabolism at 2 mM at basic pH after 5 days by 31P NMR method | 4 | ALA4177769 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4183890 | A | Drug metabolism assessed as human NTPDase1-mediated compound hydrolysis at 100 uM relative to ATP | Homo sapiens | 4 | ALA4177769 | single protein format | Scientific Literature | |
10. | ALA4183891 | A | Drug metabolism assessed as human NTPDase2-mediated compound hydrolysis at 100 uM relative to ATP | Homo sapiens | 4 | ALA4177769 | single protein format | Scientific Literature | |
11. | ALA4183892 | A | Drug metabolism assessed as human NTPDase3-mediated compound hydrolysis at 100 uM relative to ATP | Homo sapiens | 4 | ALA4177769 | single protein format | Scientific Literature | |
12. | ALA4183893 | A | Drug metabolism assessed as human NTPDase8-mediated compound hydrolysis at 100 uM relative to ATP | Homo sapiens | 4 | ALA4177769 | single protein format | Scientific Literature | |
13. | ALA4183894 | A | Drug metabolism assessed as human NPP1-mediated compound hydrolysis at 100 uM relative to ATP | Homo sapiens | 4 | ALA4177769 | single protein format | Scientific Literature | |
14. | ALA4183895 | F | Agonist activity at recombinant human P2RY2 expressed in AD293 cells assessed as increase in intracellular calcium levels by Fluo-4/AM dye-based spectrofluorometer | Homo sapiens | 4 | ALA4177769 | cell-based format | Scientific Literature | |
15. | ALA4183896 | F | Agonist activity at recombinant human P2RY4 expressed in AD293 cells assessed as increase in intracellular calcium levels by Fluo-4/AM dye-based spectrofluorometer | Homo sapiens | 4 | ALA4177769 | cell-based format | Scientific Literature | |
16. | ALA4183897 | F | Agonist activity at recombinant human P2RY6 expressed in AD293 cells assessed as increase in intracellular calcium levels by Fluo-4/AM dye-based spectrofluorometer | Homo sapiens | 4 | ALA4177769 | cell-based format | Scientific Literature | |
17. | ALA4183898 | F | Agonist activity at recombinant human P2RY6 expressed in AD293 cells assessed as increase in intracellular IP1 levels | Homo sapiens | 4 | ALA4177769 | cell-based format | Scientific Literature | |
18. | ALA4183900 | P | Drug metabolism assessed as uridine 5'-Palpha,alpha-dithiodiphosphate and inorganic phosphate formation at 2 mM at pH 1.7 at room temperature after 23 days by 31P NMR method | 1 | ALA4177769 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA4183904 | P | Drug metabolism assessed as uridine 5'-Palpha,alpha-dithiodiphosphate, uridine 5'-Palpha,alpha-dithiomonophosphate, inorganic dithiophosphate, UMP, uridine 5'-Palpha,alpha-dithio(mercaptoethylene)monophosphate and inorganic phosphate formation at 2 mM at pH 11.7 at room temperature after 25 days by 31P NMR method | 1 | ALA4177769 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA4183907 | P | Stability of the compound assessed as air oxidation at room temperature at 1.8 mM after 3 weeks by 31P NMR method | 3 | ALA4177769 | small-molecule physicochemical format | Scientific Literature |