#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4223800	B	Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substrate addition measured after 15 mins by mass spectrometric analysis	Homo sapiens	13		cell-based format	Scientific Literature
2.	ALA4223801	F	Growth inhibition of human HCC4006 cells assessed as inflection point after 5 days by cell-titer-glo luminescent cell viability assay	Homo sapiens	13		assay format	Scientific Literature
3.	ALA4223802	A	Clearance in human liver microsomes in presence of NADPH	Homo sapiens	6		microsome format	Scientific Literature
4.	ALA4223803	A	Clearance in mouse liver microsomes in presence of NADPH	Mus musculus	6		microsome format	Scientific Literature
5.	ALA4223804	A	Oral bioavailability in non-fasted mouse at 1 mg/kg administered as cassette dosing by LC/MS/MS analysis	Mus musculus	6		organism-based format	Scientific Literature
6.	ALA4223805	B	Inhibition of SPT in human HCC4006 cells assessed as reduction in ceramide content after 24 hrs in presence of C16-ceramide-d31/C14-phosphatidylcholine-d72 by LC/MS analysis	Homo sapiens	3		cell-based format	Scientific Literature
7.	ALA4223806	F	Growth inhibition of human PL21 cells after 5 days by cell-titer-glo luminescent cell viability assay	Homo sapiens	3		assay format	Scientific Literature
8.	ALA4223807	P	Thermodynamic solubility in Japanese pharmacopoeia disintegration test solution 2 at 6.8		2		small-molecule physicochemical format	Scientific Literature
9.	ALA4223808	A	Permeability of the compound from apical to basolateral side at pH 6.8 by PAMPA		2		assay format	Scientific Literature
10.	ALA4223809	A	Volume of distribution at steady state in non-fasted mouse at 0.1 mg/kg, iv administered as cassette dosing by LC/MS/MS analysis	Mus musculus	2		organism-based format	Scientific Literature
11.	ALA4223810	A	Total clearance in non-fasted mouse at 0.1 mg/kg, iv administered as cassette dosing by LC/MS/MS analysis	Mus musculus	2		organism-based format	Scientific Literature
12.	ALA4223811	A	Cmax in non-fasted mouse at 1 mg/kg, po administered as cassette dosing by LC/MS/MS analysis	Mus musculus	2		organism-based format	Scientific Literature
13.	ALA4223812	A	Tmax in non-fasted mouse at 1 mg/kg, po administered as cassette dosing by LC/MS/MS analysis	Mus musculus	2		organism-based format	Scientific Literature
14.	ALA4223813	A	AUC in non-fasted mouse at 1 mg/kg, po administered as cassette dosing by LC/MS/MS analysis	Mus musculus	2		organism-based format	Scientific Literature
15.	ALA4223814	A	MRT in non-fasted mouse at 1 mg/kg, po administered as cassette dosing by LC/MS/MS analysis	Mus musculus	2		organism-based format	Scientific Literature
16.	ALA4223815	F	In vivo inhibition of SPT in tumors of human HCC1806 cells xenografted in mouse assessed as reduction in 3-KDS levels at 10 mg/kg, po measured after 8 hrs post dose by LC/MS analysis relative to control	Mus musculus	2		organism-based format	Scientific Literature
17.	ALA4223816	F	Antitumor activity against human PL21 cells xenografted in mouse at 10 mg/kg, po administered every other day for 2 weeks relative to control	Homo sapiens	1		organism-based format	Scientific Literature
18.	ALA4223817	F	Antitumor activity against human PL21 cells xenografted in mouse at 30 mg/kg, po administered every other day for 2 weeks relative to control	Homo sapiens	1		organism-based format	Scientific Literature
19.	ALA4223818	T	Toxicity in mouse xenografted with human PL21 cells assessed as body weight loss at 10 to 30 mg/kg, po administered every other day for 2 weeks	Mus musculus	1		organism-based format	Scientific Literature