| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4219881 | Binding | Displacement of FAM-labeled HIF-1alpha peptide from VBC (unknown origin) by fluorescence polarization assay | Homo sapiens | 21 | ALA4219039 | protein complex format | Scientific Literature | |
| 2. | ALA4219882 | Binding | Binding affinity to VHL (unknown origin)/elongin C (unknown origin)/elongin B (unknown origin) by isothermal titration calorimetry-based assay | Homo sapiens | 9 | ALA4219039 | protein complex format | Scientific Literature | |
| 3. | ALA4219883 | Binding | Inhibition of VBC in human HeLa cells assessed as HIF-1alpha stabilization by measuring HIF-1alpha protein levels at 50 uM after 2 hrs by Western blot analysis | Homo sapiens | 21 | ALA4219039 | cell-based format | Scientific Literature | |
| 4. | ALA4219884 | ADME | Antiproliferative activity against human HeLa cells assessed as reduction in cell proliferation at 150 uM incubated for 24 to 72 hrs by haemocytometry | Homo sapiens | 4 | ALA4219039 | cell-based format | Scientific Literature | |
| 5. | ALA4219885 | ADME | Antiproliferative activity against human HeLa cells assessed as reduction in colony formation at 150 uM incubated for 24 hrs by crystal violet staining based assay | Homo sapiens | 4 | ALA4219039 | cell-based format | Scientific Literature | |
| 6. | ALA4219886 | ADME | Passive permeability of the compound in pH 7.4 PBS at 10 uM after 5 hrs by UPLC-MS/MS method based PAMPA | 10 | ALA4219039 | assay format | Scientific Literature | ||
| 7. | ALA4219887 | Physicochemical | Chromatographic hydrophobicity index, log D of the compound at pH 7.4 by HPLC analysis | 9 | ALA4219039 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4219888 | Binding | Binding affinity to VBC (unknown origin) assessed as association rate constant at 50 uM after 60 secs at 10 degC by surface plasmon resonance assay | Homo sapiens | 5 | ALA4219039 | protein complex format | Scientific Literature | |
| 9. | ALA4219889 | Binding | Binding affinity to VBC (unknown origin) assessed as dissociation rate constant at 50 uM after 160 secs at 10 degC by surface plasmon resonance assay | Homo sapiens | 5 | ALA4219039 | protein complex format | Scientific Literature | |
| 10. | ALA4219890 | Binding | Binding affinity to VBC (unknown origin) at 50 uM at 10 degC by surface plasmon resonance assay | Homo sapiens | 5 | ALA4219039 | protein complex format | Scientific Literature | |
| 11. | ALA4219891 | Binding | Binding affinity to VBC (unknown origin) assessed as dissociation half life at 50 uM at 10 degC by surface plasmon resonance assay | Homo sapiens | 5 | ALA4219039 | protein complex format | Scientific Literature | |
| 12. | ALA4219892 | ADME | Half life in plasma (unknown origin) at pH 7.4 at 50 uM up to 180 mins by UPLC-MS/MS analysis | Not specified | 5 | ALA4219039 | cell-free format | Scientific Literature | |
| 13. | ALA4219893 | ADME | Intrinsic clearance in CD1 mouse liver microsomes at 0.5 uM up to 30 mins by UPLC-MS/MS analysis | Mus musculus | 5 | ALA4219039 | microsome format | Scientific Literature | |
| 14. | ALA4219894 | Binding | Binding affinity to VBC (unknown origin) assessed as association rate constant at 50 uM after 60 secs at 20 degC by surface plasmon resonance assay | Homo sapiens | 5 | ALA4219039 | protein complex format | Scientific Literature | |
| 15. | ALA4219895 | Binding | Binding affinity to VBC (unknown origin) assessed as dissociation rate constant at 50 uM after 160 secs at 20 degC by surface plasmon resonance assay | Homo sapiens | 5 | ALA4219039 | protein complex format | Scientific Literature | |
| 16. | ALA4219896 | Binding | Binding affinity to VBC (unknown origin) at 50 uM at 20 degC by surface plasmon resonance assay | Homo sapiens | 5 | ALA4219039 | protein complex format | Scientific Literature | |
| 17. | ALA4219897 | Binding | Binding affinity to VBC (unknown origin) assessed as dissociation half life at 50 uM at 20 degC by surface plasmon resonance assay | Homo sapiens | 5 | ALA4219039 | protein complex format | Scientific Literature | |
| 18. | ALA4396995 | Binding | Binding affinity to VHL (unknown origin) | Homo sapiens | 1 | ALA4396864 | single protein format | Scientific Literature | |
| 19. | ALA4620018 | Binding | Inhibition of VHL (unknown origin) by fluorescence polarization assay | Homo sapiens | 5 | ALA4619711 | single protein format | Scientific Literature | |
| 20. | ALA4730314 | Binding | Displacement of FAM-labeled HIF-1alpha peptide from VCB (unknown origin) by fluorescence polarization assay | Homo sapiens | 3 | ALA4725409 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!