| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4221048 | B | Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes after 1.5 hrs by liquid scintillation counting method | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 2. | ALA4221049 | F | Antagonist activity at human CRF1 receptor expressed in CHO cells assessed as inhibition of human CRF-stimulated cAMP accumulation after 4 hrs by luciferase reporter gene assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4221050 | P | Lipophilicity, log D of the compound at pH 7.4 | 15 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4221052 | A | Stability in human liver microsomes assessed as compound clearance after 20 mins | Homo sapiens | 15 | microsome format | Scientific Literature | ||
| 5. | ALA4221053 | A | Stability in rat liver microsomes assessed as compound clearance after 20 mins | Rattus norvegicus | 2 | microsome format | Scientific Literature | ||
| 6. | ALA4221055 | F | Antagonist activity at human CRF2alpha receptor expressed in CHO cells assessed as inhibition of human CRF-stimulated cAMP accumulation after 4 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4221056 | F | Antagonist activity at human CRF2beta receptor expressed in CHO cells assessed as inhibition of human CRF-stimulated cAMP accumulation after 4 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4221057 | P | Kinetic solubility in PBS | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA4221058 | F | Ex vivo displacement of ovine [125-I]-CRF from CRF1 receptor in frontal cortex of Wistar rat at 5 and 10 mg/kg, po pretreated for 60 mins followed by decapitation measured after 2 hrs by gamma scintillation counting method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4221059 | F | Ex vivo displacement of ovine [125-I]-CRF from CRF1 receptor in frontal cortex of Wistar rat at 5 and 10 mg/kg, po pretreated for 60 mins followed by decapitation measured after 24 hrs by gamma scintillation counting method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4221060 | F | Decrease in CRF-induced locomotory activity in po dosed Wistar rat pretreated for 2 hrs followed by CRF challenge measured after 60 mins post CRF | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4221061 | A | Oral bioavailability in rat at 5 mg/kg administered as cassette dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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