| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4222273 | Functional | Antiviral activity against HIV1 3B expressing wild type reverse transcriptase infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 1 | 5 | ALA4219140 | organism-based format | Scientific Literature | |
| 2. | ALA4222274 | Functional | Antiviral activity against HIV1 RES056 expressing reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 1 | 5 | ALA4219140 | organism-based format | Scientific Literature | |
| 3. | ALA4222275 | ADME | Cytotoxicity against human MT4 cells after 5 days by MTT assay | Homo sapiens | 5 | ALA4219140 | cell-based format | Scientific Literature | |
| 4. | ALA4222276 | Toxicity | Selectivity index, ratio of CC50 for human MT4 cells to EC50 for HIV1 3B expressing wild type reverse transcriptase infected in human MT4 cells | 5 | ALA4219140 | cell-based format | Scientific Literature | ||
| 5. | ALA4222277 | Toxicity | Selectivity index, ratio of CC50 for human MT4 cells to EC50 for HIV1 RES056 expressing reverse transcriptase K103N/Y181C double mutant | 5 | ALA4219140 | assay format | Scientific Literature | ||
| 6. | ALA4222278 | Functional | Resistance index, ratio of EC50 for HIV1 RES056 harboring K103N/Y181C double mutant infected in human MT4 cells to EC50 for wild-type HIV1 3B infected in human MT4 cells | Human immunodeficiency virus 1 | 5 | ALA4219140 | organism-based format | Scientific Literature | |
| 7. | ALA4222279 | Binding | Inhibition of recombinant wild-type HIV1 reverse transcriptase p66/p51 RNA-dependent DNA polymerase activity assessed as reduction in biotin-dUTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis | Human immunodeficiency virus 1 | 2 | ALA4219140 | single protein format | Scientific Literature | |
| 8. | ALA4222281 | ADME | Prodrug conversion in human plasma assessed as RDEA427 formation by measuring remaining prodrug levels at 100 uM measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4219140 | cell-free format | Scientific Literature | |
| 9. | ALA4222282 | ADME | Prodrug conversion in human plasma assessed as RDEA427 formation by measuring remaining prodrug levels at 100 uM measured after 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4219140 | cell-free format | Scientific Literature | |
| 10. | ALA4222283 | ADME | Prodrug conversion in human plasma assessed as RDEA427 formation by measuring remaining prodrug levels at 100 uM measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4219140 | cell-free format | Scientific Literature | |
| 11. | ALA4222284 | ADME | Prodrug conversion in human plasma assessed as RDEA427 formation by measuring remaining prodrug levels at 100 uM measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4219140 | cell-free format | Scientific Literature | |
| 12. | ALA4222286 | ADME | Prodrug conversion in human plasma assessed as RDEA427 formation at 100 uM measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4219140 | cell-free format | Scientific Literature | |
| 13. | ALA4222287 | ADME | Prodrug conversion in human plasma assessed as RDEA427 formation at 100 uM measured after 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4219140 | cell-free format | Scientific Literature | |
| 14. | ALA4222288 | ADME | Prodrug conversion in human plasma assessed as RDEA427 formation at 100 uM measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4219140 | cell-free format | Scientific Literature | |
| 15. | ALA4222289 | ADME | Prodrug conversion in human plasma assessed as RDEA427 formation at 100 uM measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4219140 | cell-free format | Scientific Literature | |
| 16. | ALA4222292 | ADME | Prodrug conversion in human plasma assessed as RDEA427 formation at 100 uM by LC-MS/MS analysis | Homo sapiens | 1 | ALA4219140 | cell-free format | Scientific Literature | |
| 17. | ALA4222293 | Functional | Antiviral activity against HIV2 ROD infected in human MT4 cells after 5 days by MTT assay | Human immunodeficiency virus 2 | 1 | ALA4219140 | organism-based format | Scientific Literature |
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