| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4219406 | B | Induction of CRBN/DDB1-mediated BRD4 protein degradation in human NCI-H661 cells assessed as drug level causing 50% cellular protein depletion incubated for 4 hrs by MSD assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 2. | ALA4219407 | P | Solubility of the compound in PBS | 13 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4219408 | P | Solubility of the compound in fasted state simulated intestinal fluid | 13 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4219409 | P | Solubility of the compound in 0.01 N HCl | 13 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4219410 | B | Proteolysis targeting chimera activity in human NCI-H661 cells assessed as induction of CRBN/DDB1-mediated delivery of BRD4 for protein degradation at 1 uM after 4 hrs by Meso Scale Diagnostics assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4219411 | B | Proteolysis targeting chimera activity in human NCI-H661 cells assessed as induction of CRBN/DDB1-mediated delivery of BRD4 for protein degradation by proteasome at 1 uM after 4 hrs in presence of 10 uM of JQ-1 by Meso Scale Diagnostics assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4219412 | B | Proteolysis targeting chimera activity in human NCI-H661 cells assessed as induction of CRBN/DDB1-mediated delivery of BRD4 for protein degradation by proteasome at 1 uM after 4 hrs in presence of 10 uM thalidomide by Meso Scale Diagnostics assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4219413 | B | Proteolysis targeting chimera activity in human NCI-H661 cells assessed as induction of CRBN/DDB1-mediated delivery of BRD4 for protein degradation by proteasome at 1 uM after 4 hrs in presence of 20 uM MG132 by Meso Scale Diagnostics assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4219416 | B | Induction of human His-tagged CRBN-DDB1/GST-tagged BRD4 (49 to 170 residues) interaction assessed as CRBN/DDB1/BRD4/compound ternary complex formation preincubated for 60 mins and measured after 60 mins by luminescence based Alphascreen proximity assay relative to control | Homo sapiens | 7 | protein format | Scientific Literature |
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