# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4221741 | F | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | Homo sapiens | 14 | ALA4219121 | cell-based format | Scientific Literature | |
2. | ALA4221742 | F | Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay | Homo sapiens | 14 | ALA4219121 | cell-based format | Scientific Literature | |
3. | ALA4221743 | F | Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay | Homo sapiens | 14 | ALA4219121 | cell-based format | Scientific Literature | |
4. | ALA4221744 | F | Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay | Homo sapiens | 14 | ALA4219121 | cell-based format | Scientific Literature | |
5. | ALA4221745 | A | Antiproliferative activity against human BJ cells after 72 hrs by MTT assay | Homo sapiens | 14 | ALA4219121 | cell-based format | Scientific Literature | |
6. | ALA4221765 | B | Binding affinity to calf thymus DNA assessed as change in melting temperature at drug/DNA ratio of 0.25 by spectrophotmetric method | Bos taurus | 10 | ALA4219121 | nucleic acid format | Scientific Literature | |
7. | ALA4221766 | B | Binding affinity to calf thymus DNA assessed as change in melting temperature at drug/DNA ratio of 0.5 by spectrophotmetric method | Bos taurus | 10 | ALA4219121 | nucleic acid format | Scientific Literature | |
8. | ALA4221768 | B | Binding affinity to calf thymus DNA at 1 to 50 uM by circular dichroism spectral analysis | Bos taurus | 3 | ALA4219121 | nucleic acid format | Scientific Literature | |
9. | ALA4221771 | B | Inhibition of human topoisomerase1-mediated DNA relaxation assessed as DNA intercalation at 5 to 50 uM using supercoiled pUC19 as substrate pretreated with substrate for 45 mins followed by enzyme addition measured by agarose gel electrophoresis | Homo sapiens | 4 | ALA4219121 | single protein format | Scientific Literature | |
10. | ALA4221774 | B | Poison activity at human topoisomerase1 assessed as accumulation of nicked DNA at 20 uM using supercoiled pUC19 as substrate pretreated with substrate for 45 mins followed by enzyme addition measured by agarose gel electrophoresis relative to control | Homo sapiens | 3 | ALA4219121 | single protein format | Scientific Literature | |
11. | ALA4221777 | A | Drug uptake in human Caki2 cells at 50 uM measured after 5 hrs by Phalloidin CruzFluorTM 488 conjugate/propidium iodide staining based fluorescence microscopic analysis | Homo sapiens | 9 | ALA4219121 | cell-based format | Scientific Literature | |
12. | ALA4221778 | A | Drug uptake in nucleus of human Caki2 cells at 50 uM measured after 5 hrs by Phalloidin CruzFluorTM 488 conjugate/propidium iodide staining based fluorescence microscopic analysis | Homo sapiens | 9 | ALA4219121 | subcellular format | Scientific Literature | |
13. | ALA4221780 | A | Drug uptake in nucleolus of human Caki2 cells at 50 uM measured after 5 hrs by Phalloidin CruzFluorTM 488 conjugate/propidium iodide staining based fluorescence microscopic analysis | Homo sapiens | 1 | ALA4219121 | subcellular format | Scientific Literature | |
14. | ALA4221781 | F | Cytotoxicity against human Caki2 cells after 72 hrs by MTT assay | Homo sapiens | 9 | ALA4219121 | cell-based format | Scientific Literature |