| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4223737 | B | Inhibition of KCl-induced cytosolic voltage gated calcium channel opening in human SH-SY5Y cells at 10 uM by Fluo-4 AM dye based fluorescence assay relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA4223738 | B | Inhibition of NMDA receptor in rat cortical embryonic neurons assessed as reduction in NMDA-induced cytosolic calcium level at 10 uM by Fluo-4 AM dye based fluorescence assay relative to control | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 3. | ALA4223739 | B | Inhibition of KCl-induced cytosolic voltage gated calcium channel opening in human SH-SY5Y cells by Fluo-4 AM dye based fluorescence assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 4. | ALA4223741 | B | Reversal of okadaic acid mediated PP2A PR55alpha B regulatory subunit inactivation in human SH-SY5Y cells at 0.1 uM preincubated for 24 hrs followed by cotreatment with PPA2 inhibitor okadaic acid for 18 hrs measured over 30 mins by pNPP based spectrophotometric analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA4223742 | F | Neuroprotective activity against okadaic acid-induced cell death in human SH-SY5Y cells assessed as cell viability at 0.1 uM preincubated for 24 hrs followed by cotreatment with PPA2 inhibitor okadaic acid measured after 20 hrs by MTT assay (Rvb = 50.1 +/- 0.2%) | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 6. | ALA4478408 | B | Inhibition of VGCC in human SHSY-5Y cells assessed as reduction of K+-evoked cytosolic ca2+ at 1 uM incubated for 10 mins prior to KCl addition by Fluo-4-AM probe-based fluorescence analysis | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 7. | ALA4478410 | B | Suppression of okadaic acid-induced inhibition of PP1/PP2A in human SHSY-5Y cells at 0.1 uM using pNPP as substrate assessed as remaining total phosphatase activity incubated for 30 mins by colorimetric assay (Rvb = 68 +/- 2%) | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 8. | ALA4478411 | B | Suppression of okadaic acid-induced inhibition of PP1/PP2A in human SHSY-5Y cells at 0.1 uM using pNPP as substrate assessed as remaining Ser/Thr phosphatase activity incubated for 30 mins in presence of tyrosine phosphatase inhibitor sodium orthovanadate by colorimetric assay (Rvb = 61 +/- 3%) | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 9. | ALA4478412 | F | Neuroprotective activity in rat cortical motor neurons assessed as reversal of veratridine-induced cytotoxicity at 1 uM preincubated for 24 hrs followed by coincubation with veratridine for 24 hrs by MTT assay | Rattus norvegicus | 25 | cell-based format | Scientific Literature | ||
| 10. | ALA4478413 | F | Neuroprotective activity in human SH-SY5Y cells assessed as reversal of okadaic acid-induced cytotoxicity at 0.1 uM preincubated for 24 hrs followed by coincubation with okadaic acid for 24 hrs by MTT assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 11. | ALA4478416 | A | Cytotoxicity against human SH-SY5Y cells assessed as reduction of cell viability at <10 uM incubated for 48 hrs by MTT assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 12. | ALA4478418 | B | Inhibition of VGCC in bovine chromaffin cells assessed as reduction in depolarization-evoked Ca2+ current at 1 uM at -80 mV holding potential using 50 millisec depolarization pulses every 20 secs by patch clamp method | Bos taurus | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA4478419 | B | Inhibition of VGCC in bovine chromaffin cells assessed as potentiation of compound-induced of reduction in depolarization-evoked Ca2+ current at 1 uM at -80 mV holding potential using 50 millisec depolarization pulses every 20 secs in presence of L-type VGCC blocker nifedipine by patch clamp method | Bos taurus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4478420 | B | Inhibition of VGCC in bovine chromaffin cells assessed as reduction in depolarization-evoked Ca2+ current at 1 uM at -80 mV holding potential using 50 millisec depolarization pulses every 20 secs in presence of L-type N and P/Q type VGCC blocker omega-conotoxin MV2C by patch clamp method | Bos taurus | 1 | cell-based format | Scientific Literature |
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