# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4222778 | B | Inverse agonist activity at RORgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused to the ROR gamma ligand-binding domain assessed as inhibition of transcriptional activity after 18 hrs by luminescence-based luciferase reporter gene assay | Homo sapiens | 26 | ALA4219169 | cell-based format | Scientific Literature | |
2. | ALA4222779 | B | Inverse agonist activity at RORgamma in human CD4+ T cells assessed as inhibition of antiCD-28 antibody stimulated IL-17A production after 4 days by HTRF method | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature | |
3. | ALA4222780 | A | Fraction unbound in human plasma at 5 uM incubated for 4 hrs at 37 degC by LC-MS/MS method | Homo sapiens | 2 | ALA4219169 | cell-free format | Scientific Literature | |
4. | ALA4222781 | A | Intrinsic clearance in human hepatocytes assessed per million cells at 1 uM incubated for 5 to 90 mins by LC-MS/MS method | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature | |
5. | ALA4222782 | P | Solubility of the compound in PG/EtOH96 (3/7) solution incubated for 24 hrs by UV spectrometry | 2 | ALA4219169 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4222783 | P | Stability of the compound in PG/EtOH96 (3/7) solution at 40 degC after 1 month by HPLC analysis | 2 | ALA4219169 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4222784 | A | Phototoxicity against human neonatal keratinocytes assessed as cell viability preincubated for 30 mins before 5 J/cm2 UV light irradiation for 15 mins followed by treatment medium replacement with fresh culture medium after 24 hrs by neutral red dye-based assay | Homo sapiens | 2 | ALA4219169 | assay format | Scientific Literature | |
8. | ALA4222785 | T | Genotoxicity in Salmonella typhimurium TA98 in presence of aroclor-1254-induced rat S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | ALA4219169 | organism-based format | Scientific Literature | |
9. | ALA4222786 | T | Genotoxicity in Salmonella typhimurium TA98 in absence of aroclor-1254-induced rat S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | ALA4219169 | organism-based format | Scientific Literature | |
10. | ALA4222787 | T | Genotoxicity in Salmonella typhimurium TA100 in presence of aroclor-1254-induced rat S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | ALA4219169 | organism-based format | Scientific Literature | |
11. | ALA4222788 | T | Genotoxicity in Salmonella typhimurium TA100 in absence of aroclor-1254-induced rat S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | ALA4219169 | organism-based format | Scientific Literature | |
12. | ALA4222789 | T | Genotoxicity in human TK6 cells incubated for 27 hrs in absence of aroclor-1254-induced rat S9 fraction by Giemsa staining dependent optical microscopy based micronucleus test | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature | |
13. | ALA4222790 | T | Genotoxicity in human TK6 cells incubated for 3 hrs in presence of aroclor-1254-induced rat S9 fraction followed by 27 hrs recovery period by Giemsa staining dependent optical microscopy based micronucleus test | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature | |
14. | ALA4222791 | T | Genotoxicity in human-derived p53-competent TK6 cells expressing GADD45a-dependent green fluorescent protein assessed as decrease in cell viability after 48 hrs in presence of Sprague-Dawley rat S9 fraction by FACS analysis | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature | |
15. | ALA4222792 | T | Genotoxicity in human-derived p53-competent TK6 cells expressing GADD45a-dependent green fluorescent protein assessed as decrease in cell viability after 48 hrs in absence of Sprague-Dawley rat S9 fraction by FACS analysis | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature | |
16. | ALA4222793 | B | Inverse agonist activity at RARgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused to the RARgamma ligand-binding domain assessed as inhibition of transcriptional activity after 18 hrs by luminescence-based luciferase reporter gene assay | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature | |
17. | ALA4222794 | B | Inverse agonist activity at RORalpha (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused to the RORalpha ligand-binding domain assessed as inhibition of transcriptional activity after 18 hrs by luminescence-based luciferase reporter gene assay | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature | |
18. | ALA4222795 | B | Activity at LXRbeta (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused to the LXRbeta ligand-binding domain assessed as inhibition of transcriptional activity after 18 hrs by luminescence-based luciferase reporter gene assay | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature | |
19. | ALA4222796 | B | Activity at VDR expressed in human HeLa-derived HDLN6 cells assessed as inhibition of transcriptional activity after 18 hrs by luminescence-based luciferase reporter gene assay | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature | |
20. | ALA4222797 | B | Activity at PPARgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused to the PPARgamma ligand-binding domain assessed as inhibition of transcriptional activity after 18 hrs by luminescence-based luciferase reporter gene assay | Homo sapiens | 2 | ALA4219169 | cell-based format | Scientific Literature |