# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4222354 | B | Antagonist activity at human TLR2 expressed in HEK-blue cells assessed as inhibition of Pam3CSK4-induced NF-kappaB activation-mediated SEAP production at 25 uM after 24 hrs by Quanti-blue-based assay | Homo sapiens | 50 | ALA4219143 | cell-based format | Scientific Literature | |
2. | ALA4222355 | B | Antagonist activity at human TLR2 expressed in HEK-blue cells assessed as inhibition of Pam3CSK4-induced NF-kappaB activation-mediated SEAP production at 50 uM after 24 hrs by Quanti-blue-based assay | Homo sapiens | 50 | ALA4219143 | cell-based format | Scientific Literature | |
3. | ALA4222356 | A | Cytotoxicity against HEK-Blue cells up to 100 uM after 24 hrs by MTT assay | Homo sapiens | 1 | ALA4219143 | cell-based format | Scientific Literature | |
4. | ALA4222357 | B | Antagonist activity at human TLR1/2 expressed in HEK-blue cells assessed as inhibition of Pam3CSK4-induced NF-kappaB activation-mediated SEAP production at 25 uM after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4219143 | cell-based format | Scientific Literature | |
5. | ALA4222358 | B | Antagonist activity at human TLR2/6 expressed in HEK-blue cells assessed as inhibition of Pam2CSK4-induced NF-kappaB activation-mediated SEAP production at 25 uM after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4219143 | cell-based format | Scientific Literature | |
6. | ALA4222359 | B | Antagonist activity at human TLR3 expressed in HEK-Blue assessed as inhibition of poly 1:C-induced NF-kappaB activation-mediated SEAP production at 25 uM after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4219143 | assay format | Scientific Literature | |
7. | ALA4222360 | B | Antagonist activity at TLR2 in mouse Raw 264.7 cells assessed as decrease in Pam3CSK4-induced iNOS levels at 40 uM after 24 hrs relative to positive control | Mus musculus | 1 | ALA4219143 | cell-based format | Scientific Literature | |
8. | ALA4222361 | B | Antagonist activity at human TLR2 expressed in HEK-Blue cells assessed as inhibition of Pam3CSK4-induced TLR2 upregulation at 10 uM by Western blot analysis | Homo sapiens | 1 | ALA4219143 | cell-based format | Scientific Literature | |
9. | ALA4222362 | B | Antagonist activity at TLR2/TLR6 in mouse Raw 264.7 cells assessed as decrease in Pam2CSK4-induced iNOS levels at 40 uM after 24 hrs relative to positive control | Mus musculus | 1 | ALA4219143 | cell-based format | Scientific Literature | |
10. | ALA4222363 | B | Antagonist activity at TLR2 in human PBMC assessed as inhibition of Pam3CSK4-induced TNFalpha signalling after 24 hrs by ELISA | Homo sapiens | 1 | ALA4219143 | cell-based format | Scientific Literature | |
11. | ALA4222364 | B | Antagonist activity at TLR2 in human PBMC assessed as inhibition of Pam3CSK4-induced TNFalpha signalling at 10 uM after 24 hrs by ELISA relative to control | Homo sapiens | 1 | ALA4219143 | cell-based format | Scientific Literature |