# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4219406 | B | Induction of CRBN/DDB1-mediated BRD4 protein degradation in human NCI-H661 cells assessed as drug level causing 50% cellular protein depletion incubated for 4 hrs by MSD assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
2. | ALA4219407 | P | Solubility of the compound in PBS | 13 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA4219408 | P | Solubility of the compound in fasted state simulated intestinal fluid | 13 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA4219409 | P | Solubility of the compound in 0.01 N HCl | 13 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA4219417 | B | Induction of human His-tagged VHL(1 to 154)/GST-tagged BRD4 (49 to 170 residues) interaction assessed as VHL/BRD4/compound complex formation preincubated for 60 mins and measured after 60 mins by luminescence based Alphascreen proximity assay relative to control | Homo sapiens | 6 | protein format | Scientific Literature |