| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4223773 | B | Inhibition of human TGase 2 using R-I-Cad/DMC as substrate preincubated for 5 mins followed by substrate addition measured at 30 secs interval over 900 secs by fluorescence anisotropy assay | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 2. | ALA4223774 | B | Inhibition of guinea pig TGase 2 using F-Cad/DMC as substrate preincubated for 30 mins followed by substrate addition measured at 30 secs interval over 900 secs by fluorescence anisotropy assay | Cavia porcellus | 15 | assay format | Scientific Literature | ||
| 3. | ALA4223775 | B | Irreversible inhibition of mouse TGase 2 assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 4. | ALA4223776 | B | Irreversible inhibition of human TGase 1 assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 5. | ALA4223777 | B | Irreversible inhibition of human TGase 3 assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 6. | ALA4223778 | B | Irreversible inhibition of human TGase 6 assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 7. | ALA4223779 | B | Irreversible inhibition of human Factor 13a assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 8. | ALA4223780 | B | Inhibition of TGase 2 in human A375 cells using R-I-Cad/DMC as substrate preincubated for 5 mins followed by substrate addition measured at 30 secs interval over 900 secs by fluorescence anisotropy assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4223782 | A | Effective permeability of the compound by PAMPA assay | 22 | assay format | Scientific Literature | |||
| 10. | ALA4223783 | P | Membrane retention, RM of the compound | 19 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA4223784 | A | Chromatographic hydrophobicity index in immobilized artificial membrane at pH 7.4 by HPLC method | 19 | cell membrane format | Scientific Literature | |||
| 12. | ALA4223786 | P | Thermodynamic solubility of the compound in 0.01 M phosphate buffer at pH 7.4 at 22 degC after 39 hrs by UPLC-DAD-MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA4223787 | B | Irreversible inhibition of human TGase 2 using Z-Glu(HMC)-Gly-OH as substrate up to 25 uM measured at 20 secs interval over 900 secs by fluorimetric assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4223792 | B | Reversible inhibition of human TGase 2 using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 15. | ALA4223793 | B | Reversible inhibition of human TGase 2 assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 16. | ALA4223794 | B | Reversible inhibition of guinea pig TGase 2 assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Cavia porcellus | 3 | assay format | Scientific Literature | ||
| 17. | ALA4223795 | B | Selectivity index, ratio of Kinact/Ki for human TGase 2 to Kinact/Ki for human TGase 1 | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 18. | ALA4223796 | B | Selectivity index, ratio of Kinact/Ki for human TGase 2 to Kinact/Ki for human TGase 3 | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 19. | ALA4223797 | B | Selectivity index, ratio of Kinact/Ki for human TGase 2 to Kinact/Ki for human TGase 6 | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 20. | ALA4223798 | B | Selectivity index, ratio of Kinact/Ki for human TGase 2 to Kinact/Ki for human Factor 13a | Homo sapiens | 2 | assay format | Scientific Literature |
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