# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4222639 | Binding | Inhibition of wild type HIV1 reverse transcriptase using poly (A)/oligo (dT)15 as template/primer assessed as decrease in biotin-dUTP incorporation after 1 hr by ELISA | Human immunodeficiency virus 1 | 22 | ALA4219160 | single protein format | Scientific Literature | |
2. | ALA4222640 | Functional | Antiviral activity against wild type HIV1 3B infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 1 | 23 | ALA4219160 | organism-based format | Scientific Literature | |
3. | ALA4222641 | Functional | Antiviral activity against HIV2 ROD infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 2 | 20 | ALA4219160 | organism-based format | Scientific Literature | |
4. | ALA4222642 | ADME | Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 5 days by MTT assay | Homo sapiens | 23 | ALA4219160 | cell-based format | Scientific Literature | |
5. | ALA4222643 | Toxicity | Selectivity index, ratio of CC50 for human MT4 cells to EC50 for wild type HIV1 3B infected in human MT4 cells | 23 | ALA4219160 | cell-based format | Scientific Literature | ||
6. | ALA4222644 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase L100I mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 1 | 23 | ALA4219160 | organism-based format | Scientific Literature | |
7. | ALA4222645 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase K103N mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 1 | 23 | ALA4219160 | organism-based format | Scientific Literature | |
8. | ALA4222646 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase Y181C mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 1 | 22 | ALA4219160 | organism-based format | Scientific Literature | |
9. | ALA4222647 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase Y188L mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 1 | 22 | ALA4219160 | organism-based format | Scientific Literature | |
10. | ALA4222648 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase E138K mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 1 | 23 | ALA4219160 | organism-based format | Scientific Literature | |
11. | ALA4222649 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase F227L/V106A double mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 1 | 22 | ALA4219160 | organism-based format | Scientific Literature | |
12. | ALA4222650 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase RES056 double mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay | Human immunodeficiency virus 1 | 23 | ALA4219160 | organism-based format | Scientific Literature | |
13. | ALA4222651 | Binding | Inhibition of HIV1 reverse transcriptase K103N/Y181C double mutant using poly (A)/oligo (dT)15 as template/primer assessed as decrease in biotin-dUTP incorporation after 1 hr by ELISA | Human immunodeficiency virus 1 | 20 | ALA4219160 | single protein format | Scientific Literature |