| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4222975 | Binding | Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins by Nu-page gel-based phosphor screen analysis | Mus musculus | 21 | ALA4219184 | single protein format | Scientific Literature | |
| 2. | ALA4222976 | Functional | Antiproliferative activity against human A375 cells harboring BRAF V600E mutant after 48 hrs by MTT assay | Homo sapiens | 21 | ALA4219184 | cell-based format | Scientific Literature | |
| 3. | ALA4222977 | Functional | Antiproliferative activity against human HT-29 cells harboring BRAF V600E mutant after 48 hrs by MTT assay | Homo sapiens | 21 | ALA4219184 | cell-based format | Scientific Literature | |
| 4. | ALA4222978 | Functional | Antiproliferative activity against wild type BRAF expressing human HCT116 cells after 48 hrs by MTT assay | Homo sapiens | 21 | ALA4219184 | cell-based format | Scientific Literature | |
| 5. | ALA4222979 | Functional | Antiproliferative activity against wild type BRAF expressing human WM1361 cells after 48 hrs by MTT assay | Homo sapiens | 21 | ALA4219184 | assay format | Scientific Literature | |
| 6. | ALA4222980 | Functional | Induction of apoptosis in human A375 cells assessed as viable cells at 1 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 96.2%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 7. | ALA4222981 | Functional | Induction of apoptosis in human A375 cells assessed as early apoptotic cells at 1 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 1.19%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 8. | ALA4222982 | Functional | Induction of apoptosis in human A375 cells assessed as late apoptotic cells at 1 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 2.36%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 9. | ALA4222983 | Functional | Induction of apoptosis in human A375 cells assessed as necrotic cells at 1 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 0.227%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 10. | ALA4222984 | Functional | Induction of apoptosis in human A375 cells assessed as viable cells at 2 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 96.2%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 11. | ALA4222985 | Functional | Induction of apoptosis in human A375 cells assessed as early apoptotic cells at 2 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 1.19%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 12. | ALA4222986 | Functional | Induction of apoptosis in human A375 cells assessed as late apoptotic cells at 2 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 2.36%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 13. | ALA4222987 | Functional | Induction of apoptosis in human A375 cells assessed as necrotic cells at 2 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 0.227%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 14. | ALA4222988 | Functional | Induction of apoptosis in human A375 cells assessed as viable cells at 4 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 96.2%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 15. | ALA4222989 | Functional | Induction of apoptosis in human A375 cells assessed as early apoptotic cells at 4 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 1.19%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 16. | ALA4222990 | Functional | Induction of apoptosis in human A375 cells assessed as late apoptotic cells at 4 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 2.36%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 17. | ALA4222991 | Functional | Induction of apoptosis in human A375 cells assessed as necrotic cells at 4 uM after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 0.227%) | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 18. | ALA4222992 | Functional | Induction of apoptosis in human A375 cells after 24 hrs by Annexin V-FITC/propidium iodide double staining-based flow cytometry | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 19. | ALA4222993 | Binding | Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by Western blot analysis | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature | |
| 20. | ALA4222994 | Binding | Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in MEK phosphorylation by Western blot analysis | Homo sapiens | 1 | ALA4219184 | cell-based format | Scientific Literature |
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