| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4221852 | ADME | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 16 | ALA4219124 | microsome format | Scientific Literature | |
| 2. | ALA4221853 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 21 | ALA4219124 | microsome format | Scientific Literature | |
| 3. | ALA4221854 | Binding | Inhibition of cPLA2 (unknown origin) at 10 uM relative to control | Homo sapiens | 6 | ALA4219124 | single protein format | Scientific Literature | |
| 4. | ALA4221855 | Binding | Inhibition of recombinant human PGIS expressed in CHO cells at 10 uM relative to control | Homo sapiens | 6 | ALA4219124 | cell-based format | Scientific Literature | |
| 5. | ALA4221856 | Binding | Inhibition of TXAS (unknown origin) at 10 uM relative to control | Homo sapiens | 6 | ALA4219124 | single protein format | Scientific Literature | |
| 6. | ALA4221857 | Binding | Inhibition of human mPGES1 assessed as decrease in PGF2alpha production at 10 uM relative to control | Homo sapiens | 6 | ALA4219124 | single protein format | Scientific Literature | |
| 7. | ALA4221858 | Binding | Inhibition of cPGES in human U937 cells assessed as decrease in PGE2 production at 10 uM using arachidonic acid as substrate relative to control | Homo sapiens | 6 | ALA4219124 | cell-based format | Scientific Literature | |
| 8. | ALA4221859 | Binding | Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins followed by substrate addition measured for 1 min | Homo sapiens | 23 | ALA4219124 | cell-based format | Scientific Literature | |
| 9. | ALA4221860 | Binding | Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation with IL-1beta for 16 to 20 hrs measured after 10 mins by HTRF assay | Homo sapiens | 21 | ALA4219124 | cell-based format | Scientific Literature | |
| 10. | ALA4221861 | Binding | Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production measured after 20 to 24 hrs | Homo sapiens | 22 | ALA4219124 | single protein format | Scientific Literature | |
| 11. | ALA4221862 | ADME | Metabolic stability in guinea pig liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC-MS/MS analysis | Cavia porcellus | 21 | ALA4219124 | microsome format | Scientific Literature | |
| 12. | ALA4221863 | ADME | Inhibition of CYP1A2 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 19 | ALA4219124 | microsome format | Scientific Literature | |
| 13. | ALA4221864 | ADME | Inhibition of CYP2D6 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 19 | ALA4219124 | microsome format | Scientific Literature | |
| 14. | ALA4221865 | ADME | Inhibition of CYP3A4 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 21 | ALA4219124 | microsome format | Scientific Literature | |
| 15. | ALA4221866 | ADME | Inhibition of CYP2C9 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 21 | ALA4219124 | microsome format | Scientific Literature | |
| 16. | ALA4221867 | ADME | Inhibition of CYP2C19 in human liver microsomes at 10 uM after 40 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 21 | ALA4219124 | microsome format | Scientific Literature | |
| 17. | ALA4221868 | ADME | Protein binding in human plasma at 10 uM after 5 hrs by equilibrium dialysis based LC-MS/MS analysis | Homo sapiens | 12 | ALA4219124 | cell-free format | Scientific Literature | |
| 18. | ALA4221869 | ADME | Protein binding in guinea pig plasma at 10 uM after 5 hrs by equilibrium dialysis based LC-MS/MS analysis | Cavia porcellus | 12 | ALA4219124 | cell-free format | Scientific Literature | |
| 19. | ALA4221872 | Binding | Inhibition of human ERG at 10 uM by patch clamp assay relative to control | Homo sapiens | 8 | ALA4219124 | assay format | Scientific Literature | |
| 20. | ALA4221874 | ADME | Inhibition of human U937 cells-derived COX1 assessed as decrease in PGE2 production at 10 uM using arachidonic acid as substrate preincubated for 15 mins prior to substrate addition for 5 mins relative to control | Homo sapiens | 6 | ALA4219124 | assay format | Scientific Literature |
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