| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4222139 | ADME | Ratio of unbound plasma concentration in scopolamine-induced cognitive impairment rat model assessed as increase in time spent exploring novel object over familiar object at 1 mg/kg to IC50 for PDE2 (unknown origin) | 1 | ALA4219136 | organism-based format | Scientific Literature | ||
| 2. | ALA4222140 | Functional | Cognition enhancing effect in scopolamine-induced cognitive impairment rhesus monkey model assessed plasma concentration required to show increase in novel object retrieval at 3 mg/kg administered at 3 days interval measured twice weekly during intervals of compound dosing by novel object recognition assay | Macaca mulatta | 1 | ALA4219136 | organism-based format | Scientific Literature | |
| 3. | ALA4222141 | Binding | Antagonist activity at DP1 receptor (unknown origin) | Homo sapiens | 7 | ALA4219136 | single protein format | Scientific Literature | |
| 4. | ALA4222142 | Binding | Inhibition of PDE2 (unknown origin) | Homo sapiens | 18 | ALA4219136 | single protein format | Scientific Literature | |
| 5. | ALA4222143 | Binding | Selectivity ratio of IC50 for PDE2 (unknown origin) over IC50 for PDE3 (unknown origin) | Homo sapiens | 3 | ALA4219136 | assay format | Scientific Literature | |
| 6. | ALA4222144 | Binding | Selectivity ratio of IC50 for PDE2 (unknown origin) over IC50 for PDE4 (unknown origin) | Homo sapiens | 3 | ALA4219136 | assay format | Scientific Literature | |
| 7. | ALA4222145 | Binding | Selectivity ratio of IC50 for PDE2 (unknown origin) over IC50 for PDE5 (unknown origin) | Homo sapiens | 3 | ALA4219136 | assay format | Scientific Literature | |
| 8. | ALA4222146 | Binding | Selectivity ratio of IC50 for PDE2 (unknown origin) over IC50 for PDE6 (unknown origin) | Homo sapiens | 3 | ALA4219136 | assay format | Scientific Literature | |
| 9. | ALA4222147 | Binding | Selectivity ratio of IC50 for PDE2 (unknown origin) over IC50 for PDE7 (unknown origin) | Homo sapiens | 3 | ALA4219136 | assay format | Scientific Literature | |
| 10. | ALA4222148 | Binding | Selectivity ratio of IC50 for PDE2 (unknown origin) over IC50 for PDE8 (unknown origin) | Homo sapiens | 3 | ALA4219136 | assay format | Scientific Literature | |
| 11. | ALA4222149 | Binding | Selectivity ratio of IC50 for PDE2 (unknown origin) over IC50 for PDE9 (unknown origin) | Homo sapiens | 3 | ALA4219136 | assay format | Scientific Literature | |
| 12. | ALA4222150 | Binding | Selectivity ratio of IC50 for PDE2 (unknown origin) over IC50 for PDE10 (unknown origin) | Homo sapiens | 3 | ALA4219136 | assay format | Scientific Literature | |
| 13. | ALA4222151 | Binding | Selectivity ratio of IC50 for PDE2 (unknown origin) over IC50 for PDE11 (unknown origin) | Homo sapiens | 3 | ALA4219136 | assay format | Scientific Literature | |
| 14. | ALA4222152 | Binding | Selectivity ratio of IC50 for PDE2 (unknown origin) over IC50 for PDE1 (unknown origin) | Homo sapiens | 3 | ALA4219136 | assay format | Scientific Literature | |
| 15. | ALA4222153 | ADME | Clearance in rat | Rattus norvegicus | 1 | ALA4219136 | organism-based format | Scientific Literature | |
| 16. | ALA4222154 | ADME | Half life in rat | Rattus norvegicus | 1 | ALA4219136 | organism-based format | Scientific Literature | |
| 17. | ALA4222155 | ADME | Volume of distribution at steady state in rat | Rattus norvegicus | 1 | ALA4219136 | organism-based format | Scientific Literature | |
| 18. | ALA4222156 | ADME | Oral bioavailability in rat | Rattus norvegicus | 1 | ALA4219136 | organism-based format | Scientific Literature | |
| 19. | ALA4222157 | ADME | Protein binding in rat plasma | Rattus norvegicus | 1 | ALA4219136 | cell-free format | Scientific Literature | |
| 20. | ALA4222158 | Functional | Cognition enhancing effect in scopolamine-induced cognitive impairment rat model assessed as increase in time spent exploring novel object over familiar object by novel object recognition assay | Rattus norvegicus | 2 | ALA4219136 | organism-based format | Scientific Literature |
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