# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4221852 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 16 | microsome format | Scientific Literature | ||
2. | ALA4221853 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 21 | microsome format | Scientific Literature | ||
3. | ALA4221854 | B | Inhibition of cPLA2 (unknown origin) at 10 uM relative to control | Homo sapiens | 6 | single protein format | Scientific Literature | ||
4. | ALA4221855 | B | Inhibition of recombinant human PGIS expressed in CHO cells at 10 uM relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
5. | ALA4221856 | B | Inhibition of TXAS (unknown origin) at 10 uM relative to control | Homo sapiens | 6 | single protein format | Scientific Literature | ||
6. | ALA4221857 | B | Inhibition of human mPGES1 assessed as decrease in PGF2alpha production at 10 uM relative to control | Homo sapiens | 6 | single protein format | Scientific Literature | ||
7. | ALA4221858 | B | Inhibition of cPGES in human U937 cells assessed as decrease in PGE2 production at 10 uM using arachidonic acid as substrate relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
8. | ALA4221859 | B | Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins followed by substrate addition measured for 1 min | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
9. | ALA4221860 | B | Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation with IL-1beta for 16 to 20 hrs measured after 10 mins by HTRF assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
10. | ALA4221861 | B | Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production measured after 20 to 24 hrs | Homo sapiens | 22 | single protein format | Scientific Literature | ||
11. | ALA4221862 | A | Metabolic stability in guinea pig liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC-MS/MS analysis | Cavia porcellus | 21 | microsome format | Scientific Literature | ||
12. | ALA4221863 | A | Inhibition of CYP1A2 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 19 | microsome format | Scientific Literature | ||
13. | ALA4221864 | A | Inhibition of CYP2D6 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 19 | microsome format | Scientific Literature | ||
14. | ALA4221865 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 21 | microsome format | Scientific Literature | ||
15. | ALA4221866 | A | Inhibition of CYP2C9 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 21 | microsome format | Scientific Literature | ||
16. | ALA4221867 | A | Inhibition of CYP2C19 in human liver microsomes at 10 uM after 40 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 21 | microsome format | Scientific Literature | ||
17. | ALA4221868 | A | Protein binding in human plasma at 10 uM after 5 hrs by equilibrium dialysis based LC-MS/MS analysis | Homo sapiens | 12 | cell-free format | Scientific Literature | ||
18. | ALA4221869 | A | Protein binding in guinea pig plasma at 10 uM after 5 hrs by equilibrium dialysis based LC-MS/MS analysis | Cavia porcellus | 12 | cell-free format | Scientific Literature | ||
19. | ALA4221872 | B | Inhibition of human ERG at 10 uM by patch clamp assay relative to control | Homo sapiens | 8 | assay format | Scientific Literature | ||
20. | ALA4221873 | A | Apparent passive permeability of the compound by PAMPA | 6 | assay format | Scientific Literature |