| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4222583 | B | Antagonist activity at recombinant human P2X3 receptor expressed in Flp-In-293 cells assessed as inhibition of alphabeta-meATP-induced calcium flux preincubated for 10 mins followed by alphabeta-meATP addition measured at 5 sec intervals by Fluo-4 dye based FLIPR assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 2. | ALA4222584 | B | Antagonist activity at recombinant human P2X3 receptor expressed in Flp-In-293 cells assessed as inhibition of CTP-induced chloride current response preincubated for 2 mins followed by CTP addition along with test compound by whole cell patch-clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4222585 | F | Antinociceptive activity in complete freund's adjuvant induced mechanical hypersensitivity Sprague-Dawley rat model assessed as reversal of mechanical hyperalgesia by measuring hind paw withdrawal thresholds at 60 mg/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 4. | ALA4222586 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 5. | ALA4222589 | A | Oral bioavailability in rat | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 6. | ALA4222590 | A | Oral bioavailability in dog | Canis lupus familiaris | 2 | organism-based format | Scientific Literature | ||
| 7. | ALA4222592 | A | Protein binding in rat plasma | Rattus norvegicus | 16 | cell-free format | Scientific Literature | ||
| 8. | ALA4222593 | A | Intrinsic clearance in rat | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 9. | ALA4222594 | A | Half life in rat | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 10. | ALA4222595 | A | Protein binding in dog plasma | Canis lupus familiaris | 1 | cell-free format | Scientific Literature | ||
| 11. | ALA4222596 | A | Intrinsic clearance in dog | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4222597 | A | Half life in dog | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4222598 | A | Inhibition of UGT1A1 in human liver microsomes assessed as decrease in estradiol-3 glucuronidation | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 14. | ALA4222599 | A | Activation of PXR (unknown origin) | Homo sapiens | 6 | single protein format | Scientific Literature |
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