# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4223713 | Functional | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method | Mus musculus | 7 | ALA4219226 | cell-based format | Scientific Literature | |
2. | ALA4223714 | Functional | Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL-alpha mRNA level preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by qPCR method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
3. | ALA4223715 | Functional | Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL-beta mRNA level preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by qPCR method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
4. | ALA4223716 | Functional | Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL-6 mRNA level preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by qPCR method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
5. | ALA4223717 | Functional | Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNF-alpha mRNA level preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by qPCR method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
6. | ALA4223718 | Functional | Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNF-2 mRNA level at 50 to 100 uM preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by qPCR method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
7. | ALA4223720 | Functional | Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced COX-2 protein level at 50 to 100 uM preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by Western blot method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
8. | ALA4223721 | Binding | Inhibition of LPS-induced NFkB p65 phosphorylation in cytoplasm of human THP1 cells preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by Western blot method | Homo sapiens | 2 | ALA4219226 | assay format | Scientific Literature | |
9. | ALA4223722 | Binding | Inhibition of LPS-induced NFkB p65 nuclear translocation in human THP1 cells preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by Western blot method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
10. | ALA4223723 | Functional | Inhibition of LPS-induced STAT1 nuclear translocation in human THP1 cells at 50 to 100 uM preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by Western blot method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
11. | ALA4223724 | Functional | Inhibition of LPS-induced STAT3 nuclear translocation in human THP1 cells at 50 to 100 uM preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by Western blot method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
12. | ALA4223725 | Functional | Inhibition of LPS-induced TFEB nuclear translocation in human THP1 cells at 50 to 100 uM preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by Western blot method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
13. | ALA4223726 | Binding | Inhibition of LPS-induced TFE3 nuclear translocation in human THP1 cells at 50 to 100 uM preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by Western blot method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
14. | ALA4223728 | Binding | Inhibition of GFP-fused TFE3 (unknown origin) expressed in HEK293T cells assessed as reduction in LPS-induced TFE3 nuclear translocation at 100 uM preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by DAPI staining based confocal microscopic method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
15. | ALA4223729 | Binding | Inhibition of GFP-fused NFkB p65 (unknown origin) expressed in HEK293T cells assessed as reduction in LPS-induced p65 nuclear translocation at 100 uM preincubated for 1 hr followed by LPS stimulation measured after 12 hrs by DAPI staining based confocal microscopic method | Homo sapiens | 2 | ALA4219226 | cell-based format | Scientific Literature | |
16. | ALA4223730 | ADME | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by MTT assay | Mus musculus | 7 | ALA4219226 | cell-based format | Scientific Literature |