| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4232413 | B | Agonist activity at human PPARalpha at 5 uM after 22 to 24 hrs by luciferase reporter gene assay | Homo sapiens | 10 | ALA4229390 | single protein format | Scientific Literature | |
| 2. | ALA4232414 | B | Agonist activity at human PPARalpha at 10 uM after 22 to 24 hrs by luciferase reporter gene assay | Homo sapiens | 8 | ALA4229390 | single protein format | Scientific Literature | |
| 3. | ALA4232415 | B | Agonist activity at human PPARalpha after 22 to 24 hrs by luciferase reporter gene assay | Homo sapiens | 8 | ALA4229390 | single protein format | Scientific Literature | |
| 4. | ALA4232416 | B | Agonist activity at human PPARalpha after 22 to 24 hrs by luciferase reporter gene assay relative to GW590735 | Homo sapiens | 5 | ALA4229390 | single protein format | Scientific Literature | |
| 5. | ALA4232417 | B | Agonist activity at human PPARdelta after 22 to 24 hrs by luciferase reporter gene assay | Homo sapiens | 8 | ALA4229390 | single protein format | Scientific Literature | |
| 6. | ALA4232418 | B | Agonist activity at human PPARgamma after 22 to 24 hrs by luciferase reporter gene assay | Homo sapiens | 8 | ALA4229390 | single protein format | Scientific Literature | |
| 7. | ALA4232419 | B | Agonist activity at PPARalpha in C57BL/6N mouse assessed as upregulation of PPARalpha protein expression after 24 hrs by Western blot method | Mus musculus | 1 | ALA4229390 | assay format | Scientific Literature | |
| 8. | ALA4232420 | B | Agonist activity at PPARalpha in C57BL/6N mouse assessed as upregulation of Acadm gene expression at 10 to 100 uM after 24 hrs by RT-PCR method | Mus musculus | 1 | ALA4229390 | assay format | Scientific Literature | |
| 9. | ALA4232421 | B | Agonist activity at PPARalpha in C57BL/6N mouse assessed as upregulation of Cpt1a gene expression at 10 to 100 uM after 24 hrs by RT-PCR method | Mus musculus | 1 | ALA4229390 | assay format | Scientific Literature | |
| 10. | ALA4232422 | B | Agonist activity at PPARalpha in C57BL/6N mouse assessed as upregulation of Fabp3 gene expression at 10 to 100 uM after 24 hrs by RT-PCR method | Mus musculus | 1 | ALA4229390 | assay format | Scientific Literature | |
| 11. | ALA4232423 | B | Agonist activity at PPARalpha in C57BL/6N mouse assessed as upregulation of Slc25a20 gene expression at 10 to 100 uM after 24 hrs by RT-PCR method | Mus musculus | 1 | ALA4229390 | assay format | Scientific Literature | |
| 12. | ALA4232424 | F | Antimigratory activity in HRCEC after 10 to 24 hrs by wound healing assay | Homo sapiens | 1 | ALA4229390 | assay format | Scientific Literature | |
| 13. | ALA4232425 | B | Selectivity ratio of EC50 for human PPARdelta to EC50 for human PPARalpha | Homo sapiens | 1 | ALA4229390 | assay format | Scientific Literature | |
| 14. | ALA4232426 | B | Selectivity ratio of EC50 for human PPARgamma to EC50 for human PPARalpha | Homo sapiens | 1 | ALA4229390 | assay format | Scientific Literature | |
| 15. | ALA4344557 | A | Half life in Sprague Dawley rat pooled liver microsomes preincubated for 5 mins prior to addition of NADPH-regenerating system and measured up to 60 mins by HPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA4342468 | microsome format | Scientific Literature | |
| 16. | ALA4344558 | A | Half life in human pooled liver microsomes preincubated for 5 mins prior to addition of NADPH-regenerating system and measured up to 60 mins by HPLC-MS/MS analysis | Homo sapiens | 1 | ALA4342468 | microsome format | Scientific Literature | |
| 17. | ALA4344559 | A | Time dependent inhibition of CYP1A in human liver microsomes at 10 uM preincubated for 30 mins in presence of NADPH-generating system followed by substrate addition and measured after 10 mins by HPLC-MS/MS analysis | Homo sapiens | 1 | ALA4342468 | microsome format | Scientific Literature | |
| 18. | ALA4344560 | A | Time dependent inhibition of CYP2C9 in human liver microsomes at 10 uM preincubated for 30 mins in presence of NADPH-generating system followed by substrate addition and measured after 10 mins by HPLC-MS/MS analysis | Homo sapiens | 1 | ALA4342468 | microsome format | Scientific Literature | |
| 19. | ALA4344561 | A | Time dependent inhibition of CYP2C19 in human liver microsomes at 10 uM preincubated for 30 mins in presence of NADPH-generating system followed by substrate addition and measured after 10 mins by HPLC-MS/MS analysis | Homo sapiens | 1 | ALA4342468 | microsome format | Scientific Literature | |
| 20. | ALA4344562 | A | Time dependent inhibition of CYP2D6 in human liver microsomes at 10 uM preincubated for 30 mins in presence of NADPH-generating system followed by substrate addition and measured after 10 mins by HPLC-MS/MS analysis | Homo sapiens | 1 | ALA4342468 | microsome format | Scientific Literature |
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