Inhibition of testosterone-induced flank organ enlargement in golden hamster assessed as reduction in diameter of pigmented spot at 2 mg/kg, sc administered daily for 6 days measured post last dose by calliper method
Inhibition of testosterone-induced increase in seminal vesicle weight in golden hamster at 2 mg/kg, sc administered daily for 6 days measured post last dose
Drug metabolism in golden hamster plasma assessed as esterase-mediated 21(2-Oxo-ethyl-benzimidazol)-3-ceto, pregnen-16,17-diene formation by measuring retardation factor at 4 mg/kg, sc measured after 30 mins in presence of testosterone by TLC method
Drug metabolism in golden hamster plasma assessed as esterase-mediated 21(2-Oxo-ethyl-benzimidazol)-3-ceto, pregnen-16,17-diene formation at 4 mg/kg, sc measured after 60 to 120 mins in presence of testosterone by TLC method