# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4236899 | B | Antagonist activity at human integrin alphaVbeta6 expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BCECF-AM-fluorescence based assay | Homo sapiens | 29 | ALA4229566 | cell-based format | Scientific Literature | |
2. | ALA4236900 | B | Antagonist activity at human integrin alphaVbeta1 expressed in human A549 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BCECF-AM-fluorescence based assay | Homo sapiens | 29 | ALA4229566 | cell-based format | Scientific Literature | |
3. | ALA4236901 | B | Antagonist activity at human integrin alphaVbeta5 expressed in human K562 cells assessed as reduction in cell adhesion to vitronectin after 30 mins by BCECF-AM-fluorescence based assay | Homo sapiens | 29 | ALA4229566 | cell-based format | Scientific Literature | |
4. | ALA4236902 | B | Antagonist activity at human integrin alphaVbeta3 expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BCECF-AM-fluorescence based assay | Homo sapiens | 29 | ALA4229566 | cell-based format | Scientific Literature | |
5. | ALA4236903 | B | Antagonist activity at human integrin alphaVbeta8 expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BCECF-AM-fluorescence based assay | Homo sapiens | 29 | ALA4229566 | cell-based format | Scientific Literature | |
6. | ALA4236904 | B | Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assay | Homo sapiens | 29 | ALA4229566 | protein complex format | Scientific Literature | |
7. | ALA4236905 | B | Inhibition of human ERG expressed in HEK293 cells by Barracuda automated patch clamp assay | Homo sapiens | 29 | ALA4229566 | cell-based format | Scientific Literature | |
8. | ALA4236906 | B | Inhibition of human ERG expressed in HEK293 cells by Q-patch assay | Homo sapiens | 29 | ALA4229566 | cell-based format | Scientific Literature | |
9. | ALA4236907 | P | Lipophilicity, log D of the compound at pH 7.4 by HPLC analysis | 29 | ALA4229566 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4236908 | B | Selectivity for human integrin alphaVbeta6 over human integrin alphaVbeta1 | Homo sapiens | 20 | ALA4229566 | assay format | Scientific Literature | |
11. | ALA4236909 | B | Selectivity for human integrin alphaVbeta6 over human integrin alphaVbeta3 | Homo sapiens | 21 | ALA4229566 | assay format | Scientific Literature | |
12. | ALA4236910 | B | Selectivity for human integrin alphaVbeta6 over human integrin alphaVbeta5 | Homo sapiens | 21 | ALA4229566 | assay format | Scientific Literature | |
13. | ALA4236911 | B | Selectivity for human integrin alphaVbeta6 over human integrin alphaVbeta8 | Homo sapiens | 21 | ALA4229566 | assay format | Scientific Literature | |
14. | ALA4236926 | B | Binding affinity to human integrin alphaVbeta6 assessed as dissociation constant up to 48 hrs by liquid scintillation counting | Homo sapiens | 3 | ALA4229566 | protein complex format | Scientific Literature | |
15. | ALA4236991 | B | Binding affinity to human integrin alphaVbeta6 assessed as dissociation half life up to 48 hrs by liquid scintillation counting | Homo sapiens | 3 | ALA4229566 | protein complex format | Scientific Literature | |
16. | ALA4375392 | B | Inhibition of integrin alphavbeta1 (unknown origin) expressed in human A549 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amino acids) incubated for 30 mins by fluorescent probe BCECF-AM based fluorescence assay | Homo sapiens | 10 | ALA4373707 | cell-based format | Scientific Literature | |
17. | ALA4375393 | B | Inhibition of integrin alphavbeta3 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amino acids) incubated for 30 mins by fluorescent probe BCECF-AM based fluorescence assay | Homo sapiens | 10 | ALA4373707 | cell-based format | Scientific Literature | |
18. | ALA4375394 | B | Inhibition of integrin alphavbeta5 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to human vitronectin incubated for 30 mins by fluorescent probe BCECF-AM based fluorescence assay | Homo sapiens | 10 | ALA4373707 | cell-based format | Scientific Literature | |
19. | ALA4375395 | B | Inhibition of integrin alphavbeta8 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amino acids) incubated for 30 mins by fluorescent probe BCECF-AM based fluorescence assay | Homo sapiens | 10 | ALA4373707 | cell-based format | Scientific Literature | |
20. | ALA4375396 | B | Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amino acids) incubated for 30 mins by fluorescent probe BCECF-AM based fluorescence assay | Homo sapiens | 10 | ALA4373707 | cell-based format | Scientific Literature |