# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4236637 | Binding | Inhibition of N-terminal His-tagged BRD4 (BD1) (unknown origin) using biotinylated tetra-acetylated histone H4 peptide after 30 mins by alpha-screen assay | Homo sapiens | 8 | ALA4229554 | single protein format | Scientific Literature | |
2. | ALA4236638 | Binding | Inhibition of N-terminal His-tagged BRD4 (BD2) (unknown origin) using biotinylated tetra-acetylated histone H4 peptide after 30 mins by alpha-screen assay | Homo sapiens | 8 | ALA4229554 | single protein format | Scientific Literature | |
3. | ALA4236639 | Binding | Inhibition of N-terminal His-tagged BRD4 (BD1/BD2) (unknown origin) using biotinylated tetra-acetylated histone H4 peptide after 30 mins by alpha-screen assay | Homo sapiens | 8 | ALA4229554 | single protein format | Scientific Literature | |
4. | ALA4236640 | Binding | Binding affinity to N-terminal His-tagged BRD4 (BD1) (unknown origin) assessed as change in melting temperature at 100 uM after 0.5 hrs by SYPRO orange protein staining-based thermal denaturation assay | Homo sapiens | 6 | ALA4229554 | single protein format | Scientific Literature | |
5. | ALA4236641 | Binding | Binding affinity to N-terminal His-tagged BRD4 (BD1) (unknown origin) assessed as change in melting temperature at 100 uM after 4 hrs by SYPRO orange protein staining-based thermal denaturation assay | Homo sapiens | 5 | ALA4229554 | single protein format | Scientific Literature | |
6. | ALA4236647 | Functional | Antiproliferative activity against human MV4-11 cells after 48 hrs by cell-titer 96 aqueous one solution reagent-based assay | Homo sapiens | 2 | ALA4229554 | cell-based format | Scientific Literature | |
7. | ALA4236648 | Functional | Antiproliferative activity against human MV4-11 cells preincubated for 24 hrs by followed by compound washout measured after 48 hrs post compound washout by cell-titer 96 aqueous one solution reagent-based assay | Homo sapiens | 3 | ALA4229554 | cell-based format | Scientific Literature | |
8. | ALA4236658 | Binding | Reversible inhibition of BRD4 in human MV4-11 cells assessed as suppression of MYC mRNA levels preincubated for 4 hrs followed by compound washout measured after 4 to 24 hrs post washout by RT-PCR analysis | Homo sapiens | 1 | ALA4229554 | cell-based format | Scientific Literature | |
9. | ALA4236659 | Binding | Reversible inhibition of BRD4 in human MV4-11 cells assessed as suppression of BCL2 mRNA levels preincubated for 4 hrs followed by compound washout measured after 4 to 24 hrs post washout by RT-PCR analysis | Homo sapiens | 1 | ALA4229554 | cell-based format | Scientific Literature | |
10. | ALA4236660 | Binding | Reversible inhibition of BRD4 in human MV4-11 cells assessed as suppression of CCR1 mRNA levels preincubated for 4 hrs followed by compound washout measured after 4 to 24 hrs post washout by RT-PCR analysis | Homo sapiens | 1 | ALA4229554 | cell-based format | Scientific Literature | |
11. | ALA4236661 | Binding | Reversible inhibition of BRD4 in human MV4-11 cells assessed as suppression of GRP183 mRNA levels preincubated for 4 hrs followed by compound washout measured after 4 to 24 hrs post washout by RT-PCR analysis | Homo sapiens | 1 | ALA4229554 | cell-based format | Scientific Literature | |
12. | ALA4236662 | Binding | Reversible inhibition of BRD4 in human MV4-11 cells assessed as suppression of IL1RN mRNA levels preincubated for 4 hrs followed by compound washout measured after 4 to 24 hrs post washout by RT-PCR analysis | Homo sapiens | 1 | ALA4229554 | cell-based format | Scientific Literature | |
13. | ALA4236671 | Binding | Binding affinity to PHIP (unknown origin) assessed as change in melting temperature at 100 uM after 0.5 to 4 hrs by SYPRO orange protein staining-based thermal denaturation assay | Homo sapiens | 4 | ALA4229554 | single protein format | Scientific Literature | |
14. | ALA4236672 | Binding | Binding affinity to BRG1 (unknown origin) assessed as change in melting temperature at 100 uM after 0.5 to 4 hrs by SYPRO orange protein staining-based thermal denaturation assay | Homo sapiens | 4 | ALA4229554 | single protein format | Scientific Literature | |
15. | ALA4236673 | Binding | Binding affinity to TAF1(2) (unknown origin) assessed as change in melting temperature at 100 uM after 0.5 to 4 hrs by SYPRO orange protein staining-based thermal denaturation assay | Homo sapiens | 4 | ALA4229554 | single protein format | Scientific Literature | |
16. | ALA4236674 | Binding | Binding affinity to P300 (unknown origin) assessed as change in melting temperature at 100 uM after 0.5 to 4 hrs by SYPRO orange protein staining-based thermal denaturation assay | Homo sapiens | 4 | ALA4229554 | single protein format | Scientific Literature | |
17. | ALA4236675 | Binding | Binding affinity to BRPF1 (unknown origin) assessed as change in melting temperature at 100 uM after 0.5 to 4 hrs by SYPRO orange protein staining-based thermal denaturation assay | Homo sapiens | 4 | ALA4229554 | single protein format | Scientific Literature | |
18. | ALA4236676 | Binding | Binding affinity to CREBBP (unknown origin) assessed as change in melting temperature at 100 uM after 0.5 to 4 hrs by SYPRO orange protein staining-based thermal denaturation assay | Homo sapiens | 4 | ALA4229554 | single protein format | Scientific Literature |