| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4234011 | B | Antagonist activity at full length human FXR expressed in HeLa cells co-expressing BSEP-pGL3/pSG5-hRXR after 24 hrs by luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA4234012 | B | Antagonist activity at full length human FXR expressed in HeLa cells co-expressing BSEP-pGL3/pSG5-hRXR assessed as inhibition of GW4064-induced receptor activation after 24 hrs by luciferase reporter gene assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 3. | ALA4234013 | B | Inhibition of GW4064-induced firefly luciferase expression in HeLa cells co-expressing full length human FXR, BSEP-pGL3 and pSG5-hRXR at 1 uM treated at 23 hrs post GW4064 treatment for 1 hr by luminescence assay | Photinus pyralis | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4234014 | B | Antagonist activity at FXR in human HepG2 cells assessed as reduction in SHP mRNA expression at 10 uM after 24 hrs by RT-PCR method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4234015 | B | Antagonist activity at FXR in human HepG2 cells assessed as reduction in CDCA-induced SHP mRNA expression at 10 uM after 24 hrs by RT-PCR method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4234016 | B | Antagonist activity at FXR in human HepG2 cells assessed as reduction in GW4064-induced SHP mRNA expression at 10 uM after 24 hrs by RT-PCR method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4234017 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability up to 100 uM after 48 hrs by WST1 assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4234018 | A | Cytotoxicity against human HeLa cells co-expressing full length human FXR, BSEP-pGL3 and pSG5-hRXR assessed as reduction in cell viability up to 50 uM after 48 hrs by WST1 assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4234019 | A | Cytotoxicity against HEK293 cells assessed as reduction in cell viability at >10 uM after 48 hrs by WST1 assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4234021 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as parent compound remaining at 10 uM in presence of NADPH measured immediately by HPLC analysis | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 11. | ALA4234022 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as parent compound remaining at 10 uM in presence of NADPH measured after 15 mins by HPLC analysis | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 12. | ALA4234023 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as parent compound remaining at 10 uM in presence of NADPH measured after 30 mins by HPLC analysis | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 13. | ALA4234024 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as parent compound remaining at 10 uM in presence of NADPH measured after 60 mins by HPLC analysis | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 14. | ALA4234025 | P | Aqueous solubility of the compound | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 15. | ALA4234026 | B | Agonist activity at GAL4-fused human PPARgamma LBD expressed in HEK293T cells at 1 uM after 12 to 14 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4234027 | B | Agonist activity at GAL4-fused human CAR LBD expressed in HEK293T cells at 1 uM after 12 to 14 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4234028 | B | Agonist activity at GAL4-fused human RXRalpha LBD expressed in HEK293T cells at 1 uM after 12 to 14 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4234029 | B | Agonist activity at GAL4-fused human LXRalpha LBD expressed in HEK293T cells at 1 uM after 12 to 14 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4234030 | B | Antagonist activity at GAL4-fused human PPARgamma LBD expressed in HEK293T cells at 1 uM after 12 to 14 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4234031 | B | Antagonist activity at GAL4-fused human CAR LBD expressed in HEK293T cells at 1 uM after 12 to 14 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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