# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4236252 | Binding | Inhibition of human full length BTK using FITC-AHA-EEPLYWSFPAKKK-NH2 as substrate after 90 mins by microfluid mobility shift assay | Homo sapiens | 11 | ALA4229542 | single protein format | Scientific Literature | |
2. | ALA4236253 | ADME | Permeability from apical to basolateral side in human Caco2 cells | Homo sapiens | 9 | ALA4229542 | cell-based format | Scientific Literature | |
3. | ALA4236254 | ADME | Efflux ratio of permeability in human Caco2 cells | Homo sapiens | 9 | ALA4229542 | cell-based format | Scientific Literature | |
4. | ALA4236255 | ADME | Intrinsic clearance in human liver microsomes assessed per mg protein | Homo sapiens | 10 | ALA4229542 | microsome format | Scientific Literature | |
5. | ALA4236256 | ADME | Intrinsic clearance in mouse liver microsomes assessed per mg protein | Mus musculus | 10 | ALA4229542 | microsome format | Scientific Literature | |
6. | ALA4236257 | ADME | Intrinsic clearance in rat liver microsomes assessed per mg protein | Rattus norvegicus | 10 | ALA4229542 | microsome format | Scientific Literature | |
7. | ALA4236258 | Binding | Inhibition of BTK in human PBMC assessed as reduction in anti-IgM-induced CD69 expression incubated for 1 hr by flow cytometric analysis | Homo sapiens | 2 | ALA4229542 | cell-based format | Scientific Literature | |
8. | ALA4236259 | Binding | Inhibition of BTK in whole blood (unknown origin) | Homo sapiens | 2 | ALA4229542 | single protein format | Scientific Literature | |
9. | ALA4236260 | ADME | Fraction unbound in human plasma | Homo sapiens | 2 | ALA4229542 | cell-free format | Scientific Literature | |
10. | ALA4236261 | ADME | Fraction unbound in mouse plasma | Mus musculus | 2 | ALA4229542 | cell-free format | Scientific Literature | |
11. | ALA4236262 | ADME | Fraction unbound in rat plasma | Rattus norvegicus | 2 | ALA4229542 | cell-free format | Scientific Literature | |
12. | ALA4236263 | Binding | Binding affinity to human ERG | Homo sapiens | 2 | ALA4229542 | single protein format | Scientific Literature | |
13. | ALA4236264 | ADME | Inhibition of CYP2C8 (unknown origin) | Homo sapiens | 2 | ALA4229542 | single protein format | Scientific Literature | |
14. | ALA4236269 | ADME | Clearance in rat at 0.5 mg/kg, po | Rattus norvegicus | 2 | ALA4229542 | organism-based format | Scientific Literature | |
15. | ALA4236270 | ADME | Volume of distribution at steady state in rat at 0.5 mg/kg, po | Rattus norvegicus | 2 | ALA4229542 | organism-based format | Scientific Literature | |
16. | ALA4236271 | ADME | Half life in rat at 0.5 mg/kg, po | Rattus norvegicus | 2 | ALA4229542 | organism-based format | Scientific Literature | |
17. | ALA4236272 | ADME | Oral bioavailability in rat at 0.5 mg/kg | Rattus norvegicus | 2 | ALA4229542 | organism-based format | Scientific Literature | |
18. | ALA4236273 | Binding | Inhibition of human full length BTK at 1 uM using FITC-AHA-EEPLYWSFPAKKK-NH2 as substrate after 90 mins by microfluid mobility shift assay relative to control | Homo sapiens | 1 | ALA4229542 | single protein format | Scientific Literature | |
19. | ALA4236274 | Binding | Inhibition of Blk (unknown origin) at 1 uM relative to control | Homo sapiens | 1 | ALA4229542 | single protein format | Scientific Literature | |
20. | ALA4236275 | Binding | Inhibition of BMX (unknown origin) at 1 uM relative to control | Homo sapiens | 1 | ALA4229542 | single protein format | Scientific Literature |