| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4234433 | B | Inhibition of mouse recombinant glycolate oxidase expressed in Escherichia coli at 25 uM using glycolate as substrate after 1 min by sulfonated DCIP dye-based assay relative to control | Mus musculus | 53 | assay format | Scientific Literature | ||
| 2. | ALA4234434 | B | Inhibition of mouse recombinant glycolate oxidase expressed in Escherichia coli using glycolate as substrate by sulfonated DCIP dye-based assay | Mus musculus | 25 | assay format | Scientific Literature | ||
| 3. | ALA4234435 | B | Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as relative oxalate level at 10 uM after 24 hrs | Mus musculus | 43 | cell-based format | Scientific Literature | ||
| 4. | ALA4234437 | B | Inhibition of mouse recombinant glycolate oxidase expressed in Escherichia coli using glycolate as substrate by Dixon plot and Cornish-Bowden plot analysis | Mus musculus | 1 | assay format | Scientific Literature | ||
| 5. | ALA4234438 | B | Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production at 12.5 uM after 24 hrs post treatment relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4234439 | B | Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production at 6.25 uM after 24 hrs post treatment relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4234440 | B | Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production at 12.5 uM after 48 hrs post treatment relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4234441 | A | Cytotoxicity against C57BL/6 Agxt1-/- mouse hepatocytes after 24 to 48 hrs by Celltiter reagent based assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4234442 | B | Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 24 hrs | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4234443 | B | Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 48 hrs | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4234444 | B | Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 72 hrs | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4234448 | B | Potency index, ratio of EC50 for CCPST to EC50 for test compound for inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 24 to 72 hrs | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4234449 | B | Potency index, ratio of EC50 for CCPST to EC50 for test compound for inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 24 hrs | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4234452 | A | Half life in mouse liver microsomes at 2 uM in presence of NADPH by LC-HRMS method | Mus musculus | 2 | microsome format | Scientific Literature | ||
| 15. | ALA4234453 | A | Drug metabolism in mouse liver microsomes assessed as 2-Hydroxy-5-(5-hydroxymethylfuran-2-yl)benzoic acid formation at 2 uM in presence of NADPH after 60 mins by LC-HRMS method | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 16. | ALA4234454 | A | Drug metabolism in mouse liver microsomes assessed as 5-(5-Carboxyfuran-2-yl)-2-hydroxybenzoic acid formation at 2 uM in presence of NADPH after 60 mins by LC-HRMS method | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 17. | ALA4234455 | A | Drug metabolism in mouse liver microsomes assessed as formyl group oxidation and decarboxylation on salicylic ring at 2 uM in presence of NADPH after 60 mins by LC-HRMS method | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 18. | ALA5123586 | B | Inhibition of N-terminal His-tagged human recombinant glycolate oxidase expressed in Escherichia coli BL21 (DE3) cells using glycolate as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by Amplex red and horseradish peroxidase based fluorescence assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 19. | ALA5123587 | B | Inhibition of N-terminal His-tagged mouse recombinant glycolate oxidase expressed in Escherichia coli BL21 (DE3) cells using glycolate as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by Amplex red and horseradish peroxidase based fluorescence assay | Mus musculus | 8 | cell-based format | Scientific Literature | ||
| 20. | ALA5123590 | B | Inhibition of human recombinant LDHA using pyruvate as substrate preincubated for 10 mins followed by substrate addition and measured every 60 sec for 10 mins in the presence of NADH by fluorescence assay | Homo sapiens | 10 | single protein format | Scientific Literature |
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