| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4237183 | F | Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreated for 2.5 mins followed by acetylcholine addition and measured after 1 min by Fluo-4-AM dye based assay | Rattus norvegicus | 22 | ALA4229572 | cell-based format | Scientific Literature | |
| 2. | ALA4237184 | F | Agonist activity at rat M1 receptor expressed in CHO cells assessed as increase in calcium mobilization measured after 2.5 mins by Fluo-4-AM dye based assay | Rattus norvegicus | 20 | ALA4229572 | cell-based format | Scientific Literature | |
| 3. | ALA4237185 | F | Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreated for 2.5 mins followed by acetylcholine addition and measured after 1 min by Fluo-4-AM dye based assay | Homo sapiens | 6 | ALA4229572 | cell-based format | Scientific Literature | |
| 4. | ALA4237186 | F | Agonist activity at human M1 receptor expressed in CHO cells assessed as increase in calcium mobilization measured after 2.5 mins by Fluo-4-AM dye based assay | Homo sapiens | 6 | ALA4229572 | cell-based format | Scientific Literature | |
| 5. | ALA4237187 | A | Protein binding in rat plasma assessed as unbound fraction at 5 uL measured after 4 hrs by LC-MS/MS based equilibrium dialysis method | Rattus norvegicus | 6 | ALA4229572 | cell-free format | Scientific Literature | |
| 6. | ALA4237188 | A | Protein binding in human plasma assessed as unbound fraction at 5 uL measured after 4 hrs by LC-MS/MS based equilibrium dialysis method | Homo sapiens | 6 | ALA4229572 | cell-free format | Scientific Literature | |
| 7. | ALA4237189 | A | Protein binding in rat brain assessed as unbound fraction | Rattus norvegicus | 6 | ALA4229572 | tissue-based format | Scientific Literature | |
| 8. | ALA4237190 | A | Total brain to plasma partition coefficient, Kp in cannulated Sprague-Dawley rat at 0.2 mg/kg, iv administered via jugular vein as cassette dose measured after 0.25 hrs by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4229572 | organism-based format | Scientific Literature | |
| 9. | ALA4237191 | A | Ratio of unbound brain to plasma concentration in cannulated Sprague-Dawley rat at 0.2 mg/kg, iv administered via jugular vein as cassette dose measured after 0.25 hrs by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4229572 | organism-based format | Scientific Literature | |
| 10. | ALA4237192 | A | Total brain to plasma partition coefficient, Kp in C57BL/6J mouse at 100 mg/kg, ip after 1 hr by LC-MS/MS analysis | Mus musculus | 6 | ALA4229572 | organism-based format | Scientific Literature | |
| 11. | ALA4237193 | A | Ratio of unbound brain to plasma concentration in C57BL/6J mouse at 100 mg/kg, ip after 1 hr by LC-MS/MS analysis | Mus musculus | 6 | ALA4229572 | organism-based format | Scientific Literature | |
| 12. | ALA4237194 | T | Cholinergic toxicity in C57BL/6J mouse assessed as induction of seizure activity at 100 mg/kg, ip measured within 30 mins | Mus musculus | 5 | ALA4229572 | organism-based format | Scientific Literature |
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