# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4233071 | Binding | Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substrate addition measured after 1 hr by spectrofluorimetric method | Homo sapiens | 26 | ALA4229412 | single protein format | Scientific Literature | |
2. | ALA4233072 | Binding | Inhibition of caspase-like activity of human 20S proteasome | Homo sapiens | 3 | ALA4229412 | single protein format | Scientific Literature | |
3. | ALA4233073 | Binding | Inhibition of trypsin-like activity of human 20S proteasome | Homo sapiens | 3 | ALA4229412 | single protein format | Scientific Literature | |
4. | ALA4233074 | Functional | Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay | Homo sapiens | 14 | ALA4229412 | cell-based format | Scientific Literature | |
5. | ALA4233075 | Functional | Cytotoxicity against human U266B1 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay | Homo sapiens | 14 | ALA4229412 | cell-based format | Scientific Literature | |
6. | ALA4233076 | Functional | Cytotoxicity against human ARH77 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay | Homo sapiens | 14 | ALA4229412 | cell-based format | Scientific Literature | |
7. | ALA4233077 | ADME | Intrinsic clearance in rat liver microsomes at 1 uM incubated for 5 mins followed by NADPH addition by liquid chromatography tandem mass spectrometric method | Rattus norvegicus | 2 | ALA4229412 | microsome format | Scientific Literature | |
8. | ALA4233078 | ADME | Elimination half life in rat liver microsomes at 1 uM incubated for 5 mins followed by NADPH addition by liquid chromatography tandem mass spectrometric method | Rattus norvegicus | 2 | ALA4229412 | microsome format | Scientific Literature | |
9. | ALA4233079 | ADME | Elimination half life in mouse liver microsomes at 1 uM incubated for 5 mins followed by NADPH addition by liquid chromatography tandem mass spectrometric method | Mus musculus | 2 | ALA4229412 | microsome format | Scientific Literature | |
10. | ALA4233080 | ADME | Intrinsic clearance in mouse liver microsomes at 1 uM incubated for 5 mins followed by NADPH addition by liquid chromatography tandem mass spectrometric method | Mus musculus | 2 | ALA4229412 | microsome format | Scientific Literature | |
11. | ALA4233081 | ADME | Elimination half life in dog liver microsomes at 1 uM incubated for 5 mins followed by NADPH addition by liquid chromatography tandem mass spectrometric method | Canis lupus familiaris | 2 | ALA4229412 | microsome format | Scientific Literature | |
12. | ALA4233082 | ADME | Intrinsic clearance in dog liver microsomes at 1 uM incubated for 5 mins followed by NADPH addition by liquid chromatography tandem mass spectrometric method | Canis lupus familiaris | 2 | ALA4229412 | microsome format | Scientific Literature | |
13. | ALA4233083 | ADME | Elimination half life in monkey liver microsomes at 1 uM incubated for 5 mins followed by NADPH addition by liquid chromatography tandem mass spectrometric method | Macaca mulatta | 2 | ALA4229412 | microsome format | Scientific Literature | |
14. | ALA4233084 | ADME | Intrinsic clearance in monkey liver microsomes at 1 uM incubated for 5 mins followed by NADPH addition by liquid chromatography tandem mass spectrometric method | Macaca mulatta | 2 | ALA4229412 | microsome format | Scientific Literature | |
15. | ALA4233085 | ADME | Elimination half life in human liver microsomes at 1 uM incubated for 5 mins followed by NADPH addition by liquid chromatography tandem mass spectrometric method | Homo sapiens | 2 | ALA4229412 | microsome format | Scientific Literature | |
16. | ALA4233086 | ADME | Intrinsic clearance in human liver microsomes at 1 uM incubated for 5 mins followed by NADPH addition by liquid chromatography tandem mass spectrometric method | Homo sapiens | 2 | ALA4229412 | microsome format | Scientific Literature | |
17. | ALA4233087 | ADME | Elimination half life in Sprague-Dawley rat at 1.2 mg/kg, ig by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4229412 | organism-based format | Scientific Literature | |
18. | ALA4233088 | ADME | Elimination half life in Sprague-Dawley rat at 0.2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4229412 | organism-based format | Scientific Literature | |
19. | ALA4233089 | ADME | AUClast in Sprague-Dawley rat at 1.2 mg/kg, ig by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4229412 | organism-based format | Scientific Literature | |
20. | ALA4233090 | ADME | AUClast in Sprague-Dawley rat at 0.2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4229412 | organism-based format | Scientific Literature |