# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4231088 | Binding | Inhibition of recombinant N-terminal His6 tagged SUMO-fused Trypanosoma brucei brucei TC221 TAO MTS deletion mutant expressed in Escherichia coli FN102 preincubated for 2 mins followed by ubiquinol-1 addition measured over 2 mins by double beam-dual wavelength UV-spectrophotometry | Trypanosoma brucei brucei | 36 | ALA4229345 | assay format | Scientific Literature | |
2. | ALA4231091 | Functional | Anti-parasitic activity against bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 after 48 hrs by resazurin-based assay | Trypanosoma brucei brucei | 30 | ALA4229345 | organism-based format | Scientific Literature | |
3. | ALA4231092 | Functional | Anti-parasitic activity against bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 after 48 hrs in presence of 5 mM glycerol by resazurin-based assay | Trypanosoma brucei brucei | 30 | ALA4229345 | organism-based format | Scientific Literature | |
4. | ALA4231093 | Functional | Anti-parasitic activity against bloodstream form of Trypanosoma congolense IL3000 after 48 hrs by resazurin-based assay | Trypanosoma congolense | 27 | ALA4229345 | organism-based format | Scientific Literature | |
5. | ALA4231094 | Functional | Resistance factor, ratio of EC50 for bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 in presence of 5 mM glycerol to EC50 for bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 | Trypanosoma brucei brucei | 25 | ALA4229345 | organism-based format | Scientific Literature | |
6. | ALA4231095 | ADME | Cytotoxicity against HFF cells assessed as reduction in cell viability after 30 hrs by resazurin-based assay | Homo sapiens | 19 | ALA4229345 | cell-based format | Scientific Literature | |
7. | ALA4231097 | Functional | Anti-parasitic activity against bloodstream trypomastigote stage of Trypanosoma brucei brucei with AQP2/3-dd knock out after 48 hrs by resazurin-based assay | Trypanosoma brucei brucei | 29 | ALA4229345 | organism-based format | Scientific Literature | |
8. | ALA4231098 | Functional | Anti-parasitic activity against bloodstream trypomastigote stage of Trypanosoma brucei brucei with AQP triple knock out after 48 hrs by resazurin-based assay | Trypanosoma brucei brucei | 29 | ALA4229345 | organism-based format | Scientific Literature | |
9. | ALA4231099 | Functional | Anti-parasitic activity against bloodstream trypomastigote stage of pentamidine/diminazene/melaminophenyl arsenical resistant Trypanosoma brucei B48 after 48 hrs by resazurin-based assay | Trypanosoma brucei | 29 | ALA4229345 | organism-based format | Scientific Literature | |
10. | ALA4231100 | Functional | Resistance factor, ratio of EC50 for bloodstream trypomastigote stage of Trypanosoma brucei brucei with AQP2/3-dd knock out to EC50 for bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 | Trypanosoma brucei brucei | 25 | ALA4229345 | organism-based format | Scientific Literature | |
11. | ALA4231101 | Functional | Resistance factor, ratio of EC50 for bloodstream trypomastigote stage of Trypanosoma brucei brucei AQP triple knock out to EC50 for bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 | Trypanosoma brucei brucei | 26 | ALA4229345 | organism-based format | Scientific Literature | |
12. | ALA4231102 | Functional | Resistance factor, ratio of EC50 for bloodstream trypomastigote stage of pentamidine/diminazene/melaminophenyl arsenical resistant Trypanosoma brucei B48 to EC50 for bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 | 24 | ALA4229345 | assay format | Scientific Literature | ||
13. | ALA4231103 | Toxicity | Selectivity index, ratio of CC50 for HFF cells to EC50 for bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 | 15 | ALA4229345 | assay format | Scientific Literature |