| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4235795 | F | Inhibition of human CCR6 expressed in CHO cells assessed as decrease in CCL20-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 2. | ALA4235800 | F | Inhibition of human CCR6 expressed in CHO cells assessed as decrease in human CCL20-dependent cell migration incubated for 4 hrs by Diff-Quik staining based assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 3. | ALA4235801 | B | Inhibition of monkey CCR6 expressed in CHO cells assessed as decrease in CCL20-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay | Macaca mulatta | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA4235802 | F | Inhibition of human CCR1 expressed in CHO cells assessed as decrease in RANTES-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA4235803 | F | Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA4235804 | F | Inhibition of human CCR6 expressed in human B cells assessed as decrease in recombinant human CCL20-dependent cell migration at 0.1 to 1 uM incubated for 75 mins by Transwell assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4235805 | F | Inhibition of human CCR6 in human whole blood assessed as decrease in recombinant human CCL20-induced ERK phosphorylation after 5 mins by flow cytometry | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4235806 | A | AUC (0 to 24 hrs) in cynomolgus monkey at 0.1 mg/kg, iv | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4235807 | A | AUC (0 to 24 hrs) in cynomolgus monkey at 1 mg/kg, po | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4235808 | A | Volume of distribution at steady state in cynomolgus monkey at 0.1 mg/kg, iv or 1 mg/kg, po | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4235809 | A | Clearance in cynomolgus monkey at 0.1 mg/kg, iv or 1 mg/kg, po | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4235810 | A | Fraction unbound in cynomolgus monkey plasma at 0.1 mg/kg, iv or 1 mg/kg, po | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4235811 | A | Oral bioavailability in cynomolgus monkey at 1 mg/kg | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4235812 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4235813 | A | Inhibition of CYP2C8 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4235814 | A | Inhibition of CYP2D6 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4235815 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA4235816 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA4235817 | B | Inhibition of human ERG in presence of BSA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA4235818 | B | Inhibition of human ERG in absence of BSA | Homo sapiens | 1 | single protein format | Scientific Literature |
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