# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4235129 | F | Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as average tumor volume at 20 mg/kg, ip qd administered every consecutive day in presence of doxorubicin at 5 mg/kg/week measured on day 35 relative to control | Homo sapiens | 1 | ALA4229494 | organism-based format | Scientific Literature | |
2. | ALA4235130 | F | Induction of apoptosis in human MCF7 cells after 24 hrs by caspase-Glo 3/7 reagent based luminescence assay | Homo sapiens | 10 | ALA4229494 | cell-based format | Scientific Literature | |
3. | ALA4235131 | B | Activation of p53 in human MCF7 cell lysates assessed as increase in total p53 protein level by Western blot analysis | Homo sapiens | 1 | ALA4229494 | single protein format | Scientific Literature | |
4. | ALA4235132 | A | Metabolic stability in human liver microsomes measured at > 60 mins in presence of NADPH by HPLC analysis | Homo sapiens | 1 | ALA4229494 | microsome format | Scientific Literature | |
5. | ALA4235133 | B | Inhibition of Wnt3A-induced Wnt transcription (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by super-top flash reporter gene assay | Homo sapiens | 29 | ALA4229494 | cell-based format | Scientific Literature | |
6. | ALA4235134 | F | Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by SYBR green dye based fluorescence assay | Homo sapiens | 10 | ALA4229494 | cell-based format | Scientific Literature | |
7. | ALA4235135 | F | Antiproliferative activity against human MCF7 cells after 24 hrs by SYBR green dye based fluorescence assay | Homo sapiens | 10 | ALA4229494 | cell-based format | Scientific Literature | |
8. | ALA4235136 | B | Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase reporter gene assay | Homo sapiens | 10 | ALA4229494 | cell-based format | Scientific Literature | |
9. | ALA4235137 | P | Solubility of the compound | 8 | ALA4229494 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4235138 | P | Lipophilicity, log D of the compound at pH 3 | 8 | ALA4229494 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4235139 | P | Lipophilicity, log D of the compound at pH 7 | 8 | ALA4229494 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4235140 | F | Potentiation of doxorubicin-induced antiproliferative activity against human MCF7 cells at 8 nM after 72 hrs by SYBR green dye based fluorescence assay relative to control | Homo sapiens | 1 | ALA4229494 | cell-based format | Scientific Literature | |
13. | ALA4235141 | F | Potentiation of doxorubicin-induced antiproliferative activity against human MDA-MB-231 cells at 8 nM after 72 hrs by SYBR green dye based fluorescence assay relative to control | Homo sapiens | 1 | ALA4229494 | cell-based format | Scientific Literature | |
14. | ALA4235142 | F | Synergistic antiproliferative activity against human MCF7 cells assessed as combination index at 8 nM after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | ALA4229494 | cell-based format | Scientific Literature | |
15. | ALA4235143 | F | Synergistic antiproliferative activity against human MDA-MB-231 cells assessed as combination index at 8 nM after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | ALA4229494 | cell-based format | Scientific Literature | |
16. | ALA4235144 | F | Synergistic antiproliferative activity against human MCF7 cells assessed as combination index at ED75 after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | ALA4229494 | cell-based format | Scientific Literature | |
17. | ALA4235145 | F | Synergistic antiproliferative activity against human MDA-MB-231 cells assessed as combination index at ED75 after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | ALA4229494 | cell-based format | Scientific Literature | |
18. | ALA4235146 | F | Synergistic antiproliferative activity against human MCF7 cells assessed as combination index at ED90 after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | ALA4229494 | cell-based format | Scientific Literature | |
19. | ALA4235147 | F | Synergistic antiproliferative activity against human MDA-MB-231 cells assessed as combination index at ED90 after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | ALA4229494 | cell-based format | Scientific Literature | |
20. | ALA4235148 | B | Inhibition of human ERG up to 50 uM | Homo sapiens | 1 | ALA4229494 | single protein format | Scientific Literature |