| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4235129 | F | Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as average tumor volume at 20 mg/kg, ip qd administered every consecutive day in presence of doxorubicin at 5 mg/kg/week measured on day 35 relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4235130 | F | Induction of apoptosis in human MCF7 cells after 24 hrs by caspase-Glo 3/7 reagent based luminescence assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 3. | ALA4235131 | B | Activation of p53 in human MCF7 cell lysates assessed as increase in total p53 protein level by Western blot analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA4235132 | A | Metabolic stability in human liver microsomes measured at > 60 mins in presence of NADPH by HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 5. | ALA4235133 | B | Inhibition of Wnt3A-induced Wnt transcription (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by super-top flash reporter gene assay | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 6. | ALA4235134 | F | Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by SYBR green dye based fluorescence assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 7. | ALA4235135 | F | Antiproliferative activity against human MCF7 cells after 24 hrs by SYBR green dye based fluorescence assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 8. | ALA4235136 | B | Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase reporter gene assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 9. | ALA4235137 | P | Solubility of the compound | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 10. | ALA4235138 | P | Lipophilicity, log D of the compound at pH 3 | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA4235139 | P | Lipophilicity, log D of the compound at pH 7 | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA4235140 | F | Potentiation of doxorubicin-induced antiproliferative activity against human MCF7 cells at 8 nM after 72 hrs by SYBR green dye based fluorescence assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4235141 | F | Potentiation of doxorubicin-induced antiproliferative activity against human MDA-MB-231 cells at 8 nM after 72 hrs by SYBR green dye based fluorescence assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4235142 | F | Synergistic antiproliferative activity against human MCF7 cells assessed as combination index at 8 nM after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4235143 | F | Synergistic antiproliferative activity against human MDA-MB-231 cells assessed as combination index at 8 nM after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4235144 | F | Synergistic antiproliferative activity against human MCF7 cells assessed as combination index at ED75 after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4235145 | F | Synergistic antiproliferative activity against human MDA-MB-231 cells assessed as combination index at ED75 after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4235146 | F | Synergistic antiproliferative activity against human MCF7 cells assessed as combination index at ED90 after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4235147 | F | Synergistic antiproliferative activity against human MDA-MB-231 cells assessed as combination index at ED90 after 72 hrs in presence of doxorubicin by SYBR green dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4235148 | B | Inhibition of human ERG up to 50 uM | Homo sapiens | 1 | single protein format | Scientific Literature |
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