# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4234011 | B | Antagonist activity at full length human FXR expressed in HeLa cells co-expressing BSEP-pGL3/pSG5-hRXR after 24 hrs by luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA4234012 | B | Antagonist activity at full length human FXR expressed in HeLa cells co-expressing BSEP-pGL3/pSG5-hRXR assessed as inhibition of GW4064-induced receptor activation after 24 hrs by luciferase reporter gene assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
3. | ALA4234013 | B | Inhibition of GW4064-induced firefly luciferase expression in HeLa cells co-expressing full length human FXR, BSEP-pGL3 and pSG5-hRXR at 1 uM treated at 23 hrs post GW4064 treatment for 1 hr by luminescence assay | Photinus pyralis | 2 | cell-based format | Scientific Literature | ||
4. | ALA4234014 | B | Antagonist activity at FXR in human HepG2 cells assessed as reduction in SHP mRNA expression at 10 uM after 24 hrs by RT-PCR method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4234015 | B | Antagonist activity at FXR in human HepG2 cells assessed as reduction in CDCA-induced SHP mRNA expression at 10 uM after 24 hrs by RT-PCR method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4234016 | B | Antagonist activity at FXR in human HepG2 cells assessed as reduction in GW4064-induced SHP mRNA expression at 10 uM after 24 hrs by RT-PCR method | Homo sapiens | 2 | cell-based format | Scientific Literature |