| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4235834 | B | Inhibition of EGF-induced EGFR activation in human A431 cells pretreated for 60 mins followed by EGF addition and measured after 10 mins by ELISA | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 2. | ALA4235835 | B | Inhibition of VEGF-induced VEGFR2 activation in human U251 cells pretreated for 60 mins followed by VEGF addition and measured after 10 mins by ELISA | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 3. | ALA4235836 | B | Inhibition of PDGF-BB-induced PDGFRbeta activation in human SH-SY5Y cells pretreated for 60 mins followed by PDGF-BB addition and measured after 10 mins by ELISA | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 4. | ALA4235837 | F | Cytotoxicity against human A431 cells over-expressing EGFR | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 5. | ALA4235838 | F | Antiangiogenic activity in Leghorn chicken embryo chorioallantoic membrane after 40 hrs by microscopic analysis | Gallus gallus | 17 | tissue-based format | Scientific Literature | ||
| 6. | ALA4235839 | B | Potency index, ratio of sunitinib IC50 to test compound IC50 for VEGF-induced VEGFR2 activation in human U251 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4235840 | B | Potency index, ratio of sunitinib IC50 to test compound IC50 for PDGF-BB-induced PDGFRbeta activation in human SH-SY5Y cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4235853 | T | Toxicity in athymic nude mouse assessed as survival at 12.5 to 50 mg/kg, po administered as single dose | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4235854 | T | Toxicity in athymic nude mouse assessed as death at 100 mg/kg, po administered as single dose measured after 4 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4235855 | T | Toxicity in athymic nude mouse assessed as death at 250 to 500 mg/kg, po administered as single dose measured after 1 day | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4235856 | F | Antitumor activity against human A498 cells xenografted in athymic nude mouse assessed as reduction in tumor volume at 25 mg/kg, ip qd for 19 days measured post last dose up to 40 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4235857 | F | Antitumor activity against human A498 cells xenografted in athymic nude mouse assessed as reduction in tumor volume at 25 mg/kg, ip q2d for 19 days measured post last dose up to 40 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4235858 | F | Antitumor activity against human A498 cells xenografted in athymic nude mouse assessed as reduction in tumor volume at 25 mg/kg, ip q3d for 19 days measured post last dose up to 40 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4235859 | T | Toxicity in athymic nude mouse xenografted with human A498 cells assessed as body weight at 25 mg/kg, ip qd for 19 days measured post last dose relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4235860 | T | Toxicity in athymic nude mouse xenografted with human A498 cells assessed as body weight at 25 mg/kg, ip q2d for 19 days measured post last dose relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4235861 | T | Toxicity in athymic nude mouse xenografted with human A498 cells assessed as body weight at 25 mg/kg, ip q3d for 19 days measured post last dose relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4235862 | F | Antitumor activity against human NCI-H522 cells xenografted in athymic nude mouse | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4235863 | F | Antitumor activity against human COLO205 cells xenografted in athymic nude mouse | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4235864 | F | Antitumor activity against human NCI-H23 cells xenografted in sc dosed mouse assessed as reduction in cell viability administered daily for 4 days starting from 3 to 4 days post implantation measured post last dose by MTT based in-vivo hollow fiber assay | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4235865 | F | Antitumor activity against human NCI-H522 cells xenografted in sc dosed mouse assessed as reduction in cell viability administered daily for 4 days starting from 3 to 4 days post implantation measured post last dose by MTT based in-vivo hollow fiber assay | Homo sapiens | 1 | organism-based format | Scientific Literature |
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