| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4232709 | P | Aqueous solubility in pH 6.8 solution at 130 uM after 20 hrs by liquid chromatography method | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA4232710 | B | Inhibition of PI3Kdelta in Balb/c mouse splenocytes-derived B cells assessed as reduction in anti-IgM antibody-stimulated B cell proliferation after 2 days alamar blue assay | Mus musculus | 12 | cell-based format | Scientific Literature | ||
| 3. | ALA4232711 | B | Inhibition of recombinant human full length N-terminal His6-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf21 cells using PIP2 as substrate after 35 to 40 mins by HTRF assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 4. | ALA4232712 | B | Selectivity ratio of IC50 for recombinant human full length N-terminal His6-tagged PI3K p110alpha/p85alpha expressed in baculovirus infected Sf21 cells to IC50 for recombinant human full length N-terminal His6-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf21 cells | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 5. | ALA4232713 | B | Selectivity ratio of IC50 for recombinant human full length N-terminal His6-tagged PI3K p110beta/p85alpha expressed in baculovirus infected Sf21 cells to IC50 for recombinant human full length N-terminal His6-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf21 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4232714 | B | Selectivity ratio of IC50 for recombinant human full length N-terminal His6-tagged PI3K p120gamma expressed in baculovirus infected Sf21 cells to IC50 for recombinant human full length N-terminal His6-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf21 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4232716 | A | Intrinsic clearance in CD-1 mouse liver microsomes at 0.2 uM up to 45 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 6 | microsome format | Scientific Literature | ||
| 8. | ALA4232717 | A | Permeability of the compound at 50 uM after 2 hrs by HPLC based PAMPA | 1 | assay format | Scientific Literature | |||
| 9. | ALA4232718 | A | Inhibition of CYP1A2 in human liver microsomes at 5 uM using phenacetin as substrate after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 10. | ALA4232719 | A | Inhibition of CYP2C8 in human liver microsomes at 5 uM using amodiaquine as substrate after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 11. | ALA4232720 | A | Inhibition of CYP2C9 in human liver microsomes at 5 uM using diclofenac as substrate after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 12. | ALA4232721 | A | Inhibition of CYP2C19 in human liver microsomes at 5 uM using S-mephenytoin as substrate after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 13. | ALA4232722 | A | Inhibition of CYP2D6 in human liver microsomes at 5 uM using dextromethorphan as substrate after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 14. | ALA4232723 | A | Inhibition of CYP3A4 in human liver microsomes at 5 uM using midazolam as substrate after 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 15. | ALA4232724 | A | Total clearance in Balb/c mouse at 1 mg/kg, iv or 3 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4232725 | A | Volume of distribution at steady state in Balb/c mouse at 1 mg/kg, iv or 3 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4232726 | A | Half life in Balb/c mouse at 1 mg/kg, iv or 3 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4232727 | A | Cmax in Balb/c mouse at 1 mg/kg, iv or 3 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4232728 | A | Tmax in Balb/c mouse at 1 mg/kg, iv or 3 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4232729 | A | AUC (0 to 24 hrs) in Balb/c mouse at 1 mg/kg, iv or 3 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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