| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4266930 | B | Agonist activity at human TLR7 expressed in HEK293 cells after 6 hrs by NFkappaB-luciferase reporter gene assay | Homo sapiens | 52 | cell-based format | Scientific Literature | ||
| 2. | ALA4266931 | B | Agonist activity at human TLR8 expressed in HEK293 cells after 6 hrs by NFkappaB-luciferase reporter gene assay | Homo sapiens | 52 | cell-based format | Scientific Literature | ||
| 3. | ALA4266932 | A | Cytotoxicity against HEK293 cells transfected with the CMV-TLR7 construct assessed as reduction in cell viability after 6 hrs by ATPlite assay | Homo sapiens | 51 | cell-based format | Scientific Literature | ||
| 4. | ALA4266934 | B | Agonist activity at TLR7 in human PBMC assessed as suppression of HCV replicon replication in human HuH7 luc/neo cells harboring RNA encoding bicistronic expression construct comprising wild type HCV type 1b NS3-NS5B regions exposed to conditioned media from compound treated PBMCs after 24 hrs by luciferase reporter gene assay | Homo sapiens | 37 | cell-based format | Scientific Literature | ||
| 5. | ALA4266935 | B | Displacement of 3H-dofetilide from human ERG | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 6. | ALA4266936 | A | Drug metabolism in mouse liver microsomes at 1 uM after 15 mins | Mus musculus | 6 | microsome format | Scientific Literature | ||
| 7. | ALA4266937 | A | Drug metabolism in human liver microsomes at 1 uM after 15 mins | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 8. | ALA4266938 | A | Tmax in C57BL/6 mouse plasma at 5 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4266939 | A | Cmax in C57BL/6 mouse plasma at 5 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4266940 | A | Cmax in C57BL/6 mouse liver at 5 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4266941 | A | AUC (0 to last) in C57BL/6 mouse plasma at 5 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4266942 | A | AUC (0 to last) in C57BL/6 mouse liver at 5 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4266943 | A | Protein binding in mouse plasma | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 14. | ALA4266944 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4266945 | A | Inhibition of CYP2C8 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4266946 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4266947 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA4266948 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA4266949 | A | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA4266950 | F | Induction of innate immune response in C57BL/6 mouse assessed as IFNalpha Cmax in plasma at 5 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!