| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4251893 | B | State-dependent inhibition of human NaV1.7 expressed in HEK293 cells at -20 mV holding potential after 5 mins by IonWorks barracuda electrophysiology method | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 2. | ALA4251894 | A | Inhibition of human NaV1.5 expressed in HEK293 cells at -50 mV holding potential after 3 to 5 mins by PatchXpress 7000A electrophysiology method | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 3. | ALA4251895 | B | Selectivity ratio of IC50 for human NaV1.5 to IC50 for state-dependent inhibition of human NaV1.7 | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 4. | ALA4251896 | A | Intrinsic clearance in human liver microsomes at 1 uM after 1 to 40 mins by LC-MS/MS analysis | Homo sapiens | 22 | microsome format | Scientific Literature | ||
| 5. | ALA4251897 | P | Thermodynamic solubility of the compound in PBS at pH 7.4 | 22 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4251899 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 4 | microsome format | Scientific Literature | ||
| 7. | ALA4251900 | A | Fraction unbound in mouse plasma | Mus musculus | 3 | cell-free format | Scientific Literature | ||
| 8. | ALA4251901 | A | Cmax in mouse at 100 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA4251902 | A | Unbound Cmax in mouse at 100 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA4251903 | A | Half life in mouse at 100 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4251904 | A | Apparent oral clearance in mouse at 100 mg/kg | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4251905 | B | State-dependent inhibition of human NaV1.7 expressed in HEK293 cells at -50 mV holding potential after 3 to 5 mins by PatchXpress 7000A electrophysiology method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4251906 | B | State-dependent inhibition of mouse NaV1.7 expressed in HEK293 cells at -20 mV holding potential after 5 mins by IonWorks barracuda electrophysiology method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4251907 | B | State-dependent inhibition of mouse NaV1.7 expressed in HEK293 cells at -50 mV holding potential after 3 to 5 mins by PatchXpress 7000A electrophysiology method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4251908 | A | Apparent permeability across MDCK cells transfected with MDR1 | Canis lupus familiaris | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4251909 | A | Substrate activity at p-gp (unknown origin) assessed as efflux ratio | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 17. | ALA4251910 | A | Substrate activity at BCRP (unknown origin) assessed as efflux ratio | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 18. | ALA4251911 | F | Reduction of scratching behavior in C57Bl/6 mouse histamine dichloride-induced pruritus model at 300 mg/kg, po administered 60 mins prior to histamine dichloride challenge measured over 30 mins relative to vehicle-treated control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4251913 | A | Plasma concentration in C57Bl/6 mouse histamine dichloride-induced pruritus model at 300 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4251914 | A | Unbound plasma concentration in C57Bl/6 mouse histamine dichloride-induced pruritus model at 300 mg/kg, po measured at 1.5 hrs | Mus musculus | 1 | organism-based format | Scientific Literature |
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