# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4275884 | B | Binding affinity to bovine articular cartilage aggrecan at 500 uM by SPR analysis | Bos taurus | 12 | ALA4270645 | single protein format | Scientific Literature | |
2. | ALA4275885 | B | Binding affinity to bovine articular cartilage aggrecan by SPR analysis | Bos taurus | 13 | ALA4270645 | single protein format | Scientific Literature | |
3. | ALA4275886 | A | Antiproliferative activity against human HEMC-SS cells treated for 24 hrs under normoxic condition followed by compound wash-out and incubated under normoxic condition for 48 hrs by alamar blue assay | Homo sapiens | 14 | ALA4270645 | cell-based format | Scientific Literature | |
4. | ALA4275887 | F | Antiproliferative activity against human HEMC-SS cells treated for 24 hrs under hypoxic condition followed by compound wash-out and incubated under normoxic condition for 48 hrs by alamar blue assay | Homo sapiens | 14 | ALA4270645 | cell-based format | Scientific Literature | |
5. | ALA4275888 | F | Selectivity index, ratio of IC50 for human HEMC-SS cells under normoxic condition to IC50 for human HEMC-SS cells under hypoxic condition | Homo sapiens | 14 | ALA4270645 | cell-based format | Scientific Literature | |
6. | ALA4275895 | A | Prodrug activation in pH 7.4 PBS buffer assessed as 25 ug/ml Escherichia coli nitroreductase-mediated corresponding phosphoramidate anion formation by measuring half life at 37 degC in presence of NADPH by RP-HPLC analysis | Escherichia coli | 1 | ALA4270645 | assay format | Scientific Literature | |
7. | ALA4275896 | A | Prodrug activation in pH 7.4 PBS buffer assessed as 15 ug/ml Escherichia coli nitroreductase-mediated corresponding phosphoramidate anion formation by measuring half life at 37 degC in presence of NADPH by RP-HPLC analysis | Escherichia coli | 1 | ALA4270645 | assay format | Scientific Literature |