| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4256752 | B | Inhibition of NLRP3 in mouse J774A.1 cells assessed as reduction in LPS-stimulated IL-1beta levels pre-incubated with LPS for 4.5 hrs followed by incubation for 30 mins in presence of ATP and measured after 30 mins by ELISA | Mus musculus | 29 | cell-based format | Scientific Literature | ||
| 2. | ALA4256753 | B | Inhibition of NLRP3 in mouse BMDM assessed as reduction in LPS-stimulated IL-1beta levels pre-incubated with LPS for 4.5 hrs followed by incubation for 30 mins in presence of ATP and measured after 30 mins by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4256755 | B | Inhibition of AIM2 in mouse J774A.1 cells assessed as reduction in LPS-stimulated IL-1beta levels at 10 uM incubated for 1 hr with LPS followed by flagellin stimulation for 6 hrs by ELISA | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA4256756 | B | Inhibition of NLRC4 in mouse J774A.1 cells assessed as reduction in LPS-stimulated IL-1beta levels at 10 uM incubated for 1 hr with LPS followed by (poly(dA:dT)) stimulation for 8 hrs by ELISA | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA4256757 | F | In-vivo inhibition of NLRP3 inflammasome in C57BL/6 mouse assessed as reduction in LPS-induced IL-1beta levels at 0.5 mg/kg, ip pre-treated for 1 hr followed by LPS stimulation for 2.5 hrs by ELISA | Mus musculus | 3 | organism-based format | Scientific Literature |
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