# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4257109 | B | Inhibition of rat NHE3 expressed in OK cells assessed as reduction in Na+ dependent H+ antiport in presence of NHE1 inhibitor EIPA by BCECF-AM dye based fluorescence assay | Rattus norvegicus | 182 | cell-based format | Patent Bioactivity Data | ||
2. | ALA4257110 | B | Inhibition of human NHE3 expressed in OK cells assessed as reduction in Na+ dependent H+ antiport in presence of NHE1 inhibitor EIPA by BCECF-AM dye based fluorescence assay | Homo sapiens | 169 | cell-based format | Patent Bioactivity Data | ||
3. | ALA4257111 | F | In vivo inhibition of NHE3 in Sprague-Dawley rat assessed as inhibition of sodium absorption from intestinal lumen by measuring urinary sodium concentration at 10 mg/kg, po via gavage measured after 16 hrs relative to control | Rattus norvegicus | 126 | organism-based format | Patent Bioactivity Data | ||
4. | ALA4257141 | B | Inhibition of rat NHE3 expressed in OK cells assessed as reduction in Na+ dependent H+ antiport co-treated with NaCl-HEPES buffer for 60 mins followed by compound washout and subsequent incubation for 30 mins in presence of NaCl-HEPES buffer by BCECF-AM dye based fluorescence assay | Rattus norvegicus | 5 | cell-based format | Patent Bioactivity Data | ||
5. | ALA4257142 | B | Inhibition of human NHE3 expressed in OK cells assessed as reduction in Na+ dependent H+ antiport co-treated with NaCl-HEPES buffer for 60 mins followed by compound washout and subsequent incubation for 30 mins in presence of NaCl-HEPES buffer by BCECF-AM dye based fluorescence assay | Homo sapiens | 5 | cell-based format | Patent Bioactivity Data | ||
6. | ALA4257143 | B | Inhibition of human Nap2B isoform-A expressed in HEK293 cells assessed as reduction in sodium-dependent 33Pi uptake after 23 mins by TopCount liquid scintillation counting method | Homo sapiens | 5 | cell-based format | Patent Bioactivity Data |