# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4270179 | A | Cytotoxicity against rat PC12 cells assessed as reduction in cell viability at 10 uM after 24 hrs by MTT assay | Rattus norvegicus | 15 | ALA4266049 | cell-based format | Scientific Literature | |
2. | ALA4270180 | F | Cytoprotective activity against H2O2-induced oxidative injury in rat PC12 cells assessed as cell viability at 10 uM pretreated for 24 hrs followed by 350 uM H2O2 challenge measured after 24 hrs by MTT assay (Rvb = 60%) | Rattus norvegicus | 2 | ALA4266049 | cell-based format | Scientific Literature | |
3. | ALA4270182 | F | Cytoprotective activity against H2O2-induced oxidative injury in rat PC12 cells assessed as reduction in cell viability at 10 uM pretreated for 24 hrs followed by 500 uM H2O2 challenge measured after 24 hrs by MTT assay | Rattus norvegicus | 3 | ALA4266049 | cell-based format | Scientific Literature | |
4. | ALA4270183 | F | Cytoprotective activity against H2O2-induced oxidative injury in rat PC12 cells assessed as increase in colony formation at 1 to 2 uM pretreated for 24 hrs followed by H2O2 challenge by crystal violet staining based assay | Rattus norvegicus | 1 | ALA4266049 | cell-based format | Scientific Literature | |
5. | ALA4270185 | F | Cytoprotective activity against H2O2-induced oxidative injury in rat PC12 cells assessed as decrease in LDH release after 24 hrs | Rattus norvegicus | 1 | ALA4266049 | cell-based format | Scientific Literature | |
6. | ALA4270186 | F | Cytoprotective activity against H2O2-induced oxidative injury in rat PC12 cells assessed as inhibition of MDA production pretreated for 24 hrs followed by H2O2 challenge measured after 16 hrs | Rattus norvegicus | 1 | ALA4266049 | cell-based format | Scientific Literature | |
7. | ALA4270188 | F | Cytoprotective activity against H2O2-induced oxidative injury in rat PC12 cells assessed as reduction in intracellular reactive oxygen species formation pretreated for 24 hrs followed by H2O2 challenge measured after 3 hrs by DCFH-DA dye based fluorescence microscopic analysis | Rattus norvegicus | 1 | ALA4266049 | cell-based format | Scientific Literature | |
8. | ALA4270190 | B | Inhibition of Keap1/Nrf2 signaling in rat PC12 cells assessed as induction of nuclear translocation at 10 uM after 6 hrs by DAPI staining based fluorescence microscopic analysis | Rattus norvegicus | 1 | ALA4266049 | cell-based format | Scientific Literature | |
9. | ALA4270191 | B | Inhibition of Keap1/Nrf2 signaling in rat PC12 cells assessed as induction of ARE by measuring increase in HO-1 expression after 24 hrs by Western blot analysis | Rattus norvegicus | 1 | ALA4266049 | cell-based format | Scientific Literature | |
10. | ALA4270193 | F | Cytoprotective activity against H2O2-induced oxidative injury in rat PC12 cells harboring siRNA assessed as increase in cell viability at 10 uM pretreated for 24 hrs followed by H2O2 challenge measured after 24 hrs by MTT assay | Rattus norvegicus | 1 | ALA4266049 | cell-based format | Scientific Literature | |
11. | ALA4270194 | F | Cytoprotective activity against H2O2-induced oxidative injury in rat PC12 cells harboring siRNA assessed as increase in colony formation at 2 uM pretreated for 24 hrs followed by H2O2 challenge by crystal violet staining based assay | Rattus norvegicus | 1 | ALA4266049 | cell-based format | Scientific Literature | |
12. | ALA4270195 | F | Cytoprotective activity against H2O2-induced oxidative injury in rat PC12 cells harboring Nrf2 siRNA assessed as increase in cell viability at 10 uM pretreated for 24 hrs followed by H2O2 challenge measured after 24 hrs by MTT assay | Rattus norvegicus | 1 | ALA4266049 | cell-based format | Scientific Literature | |
13. | ALA4270196 | F | Cytoprotective activity against H2O2-induced oxidative injury in rat PC12 cells harboring Nrf2 siRNA assessed as increase in colony formation at 2 uM pretreated for 24 hrs followed by H2O2 challenge by crystal violet staining based assay | Rattus norvegicus | 1 | ALA4266049 | cell-based format | Scientific Literature |