# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4260469 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as GSH depletion at 500 uM after 3 to 12 hrs by ThiolTracker Violet dye-based fluorescence assay | Homo sapiens | 4 | ALA4257568 | cell-based format | Scientific Literature | |
2. | ALA4260470 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as GSH depletion at 500 uM measured over 12 hrs by ThiolTracker Violet dye-based fluorescence assay | Homo sapiens | 4 | ALA4257568 | cell-based format | Scientific Literature | |
3. | ALA4260471 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as GSH depletion at 1000 uM after 12 hrs by ThiolTracker Violet dye-based fluorescence assay | Homo sapiens | 4 | ALA4257568 | cell-based format | Scientific Literature | |
4. | ALA4260472 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as necrotic cell death at 500 uM measured over 12 hrs by LDH assay | Homo sapiens | 4 | ALA4257568 | cell-based format | Scientific Literature | |
5. | ALA4260473 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as necrotic cell death at 1000 uM measured over 12 hrs by LDH assay | Homo sapiens | 3 | ALA4257568 | cell-based format | Scientific Literature | |
6. | ALA4260474 | ADME | Inhibition of human CYP3A4 expressed in baculosomes at 1 uM using BOMCC as substrate preincubated for 20 mins followed by substrate and NADP+ addition and measured after 30 mins by fluorescence assay | Homo sapiens | 4 | ALA4257568 | assay format | Scientific Literature | |
7. | ALA4260475 | ADME | Inhibition of human CYP2E1 expressed in baculosomes at 1 uM using EOMCC as substrate preincubated for 20 mins followed by substrate and NADP+ addition and measured after 30 mins by fluorescence assay | Homo sapiens | 4 | ALA4257568 | assay format | Scientific Literature | |
8. | ALA4260476 | ADME | Inhibition of human CYP2D6 expressed in baculosomes at 1 uM using MOBFC as substrate preincubated for 20 mins followed by substrate and NADP+ addition and measured after 30 mins by fluorescence assay | Homo sapiens | 3 | ALA4257568 | assay format | Scientific Literature | |
9. | ALA4260477 | Functional | Antipyretic activity in LPS-induced CD1 mouse fever model assessed as effect on rectal temperature at 50 ug/kg, po administered as single dose and measured every 2 hrs up to 24 hrs | Mus musculus | 3 | ALA4257568 | organism-based format | Scientific Literature |