# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4268524 | Functional | Antiplasmodial activity against drug-sensitive asexual ring stage Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay | Plasmodium falciparum | 26 | ALA4265952 | organism-based format | Scientific Literature | |
2. | ALA4268525 | Functional | Antiplasmodial activity against multidrug-resistant asexual ring stage Plasmodium falciparum Dd2 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay | Plasmodium falciparum | 26 | ALA4265952 | organism-based format | Scientific Literature | |
3. | ALA4268526 | Functional | Resistance index, ratio of IC50 for multidrug-resistant asexual ring stage Plasmodium falciparum Dd2 infected in human erythrocytes to IC50 for drug-sensitive asexual ring stage Plasmodium falciparum 3D7 infected in human erythrocytes | 25 | ALA4265952 | cell-based format | Scientific Literature | ||
4. | ALA4268527 | ADME | Cytotoxicity against human NFF cells | Homo sapiens | 26 | ALA4265952 | cell-based format | Scientific Literature | |
5. | ALA4268528 | Toxicity | Selectivity index, ratio of IC50 for human NFF cells to IC50 for drug-sensitive asexual ring stage Plasmodium falciparum 3D7 infected in human erythrocytes | 26 | ALA4265952 | cell-based format | Scientific Literature | ||
6. | ALA4268529 | Toxicity | Selectivity index, ratio of IC50 for human NFF cells to IC50 for multidrug-resistant asexual ring stage Plasmodium falciparum Dd2 infected in human erythrocytes | 26 | ALA4265952 | cell-based format | Scientific Literature | ||
7. | ALA4268530 | Functional | Cytotoxicity against human HepG2A16 cells expressing GFP-fused CD81 after 48 hrs by bioluminescence assay | Homo sapiens | 13 | ALA4265952 | cell-based format | Scientific Literature | |
8. | ALA4268531 | Toxicity | Selectivity index, ratio of IC50 for human HepG2A16 cells to IC50 for drug-sensitive asexual ring stage Plasmodium falciparum 3D7 infected in human erythrocytes | 12 | ALA4265952 | cell-based format | Scientific Literature | ||
9. | ALA4268532 | Toxicity | Selectivity index, ratio of IC50 for human HepG2A16 cells to IC50 for multidrug-resistant asexual ring stage Plasmodium falciparum Dd2 infected in human erythrocytes | 12 | ALA4265952 | cell-based format | Scientific Literature | ||
10. | ALA4268535 | Binding | Inhibition of HDAC in synchronized trophozoite stage Plasmodium falciparum 3D7 infected in human erythrocytes assessed as increase in acetylated H4 level at 5 times IC50 after 3 hrs by Western blot analysis relative to control | Plasmodium falciparum 3D7 | 12 | ALA4265952 | cell-based format | Scientific Literature | |
11. | ALA4268542 | Functional | Antiplasmodial activity against exo-erythrocytic stage of GFP-Luc-fused Plasmodium berghei ANKA infected in human HepG2 cells after 48 hrs by bioluminescence assay | Plasmodium berghei | 13 | ALA4265952 | organism-based format | Scientific Literature | |
12. | ALA4268543 | Toxicity | Selectivity index, ratio of IC50 for human HepG2A16 cells to IC50 for exo-erythrocytic stage of GFP-Luc-fused Plasmodium berghei ANKA infected in human HepG2 cells | 13 | ALA4265952 | cell-based format | Scientific Literature |